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|Application / Reactivity||Mouse (Murine)|
|Blocking Antibody (Inhibition)||2 Antibodies|
|Blocking Peptide (BP)||5 Antibodies|
|Electron Microscopy (EM)||1 Antibodies|
|Enzyme Immunoassay (EIA)||5 Antibodies|
|Flow Cytometry (FACS)||19 Antibodies|
|Functional Studies (Func)||6 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||7 Antibodies|
|Immunofluorescence (IF)||8 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||12 Antibodies|
|Immunohistochemistry (IHC)||46 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||5 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||31 Antibodies|
|Immunoprecipitation (IP)||14 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Antigen||Interleukin 1, beta (IL1B) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL1B antibody is un-conjugated Alternatives|
Neutralization (Neut), Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-IL1B AntibodyTarget Details IL1B Application Details Handling References for anti-IL1B Antibody (ABIN223538) Images
|Immunogen||E. coli expressed murine IL-1beta|
Target Details IL1BProduct Details anti-IL1B Antibody Application Details Handling References for anti-IL1B Antibody (ABIN223538) Images back to top
|Alternative Name||IL-1b (IL1B Antibody Abstract)|
IL-1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine. Recombinant murine IL-1beta is a 17.5 kDa protein containing 153 amino acid residues.
Synonyms: IL-1 beta, IL1 beta, IL 1 beta, Interluekin-1 beta, Interluekin 1 beta, interluekin
|Research Area||Cytokines, Immunology, Virology, Inflammation, Cancer|
|Pathways||NF-kappaB Signaling, TCR Signaling, Interferon-gamma Pathway|
Application DetailsProduct Details anti-IL1B Antibody Target Details IL1B Handling References for anti-IL1B Antibody (ABIN223538) Images back to top
Western blot analysis (0.5-4 μg/mL). Neutralization studies.
Recombinant murine IL-1β can be used as a positive control.
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL1B Antibody Target Details IL1B Application Details References for anti-IL1B Antibody (ABIN223538) Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit anti-murine IL-1β polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 %BSA and 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-IL1B Antibody (ABIN223538)Product Details anti-IL1B Antibody Target Details IL1B Application Details Handling Images back to top
|Product cited in:||
Wang, Viollet, Terkeltaub, Liu-Bryan: "AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages." in: Annals of the rheumatic diseases, 2014
Zhang, Xu, Ma, Wu, Wang, Zhou, Han: "Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 7, pp. 3517-24, 2013
Martin, Shaw, Liu, Steiger, Harper: "MSU crystal-recruited non-inflammatory monocytes differentiate into M1-like pro-inflammatory macrophages in a peritoneal murine model of gout." in: Arthritis and rheumatism, 2011
Martin, Shaw, Liu, Steiger, Harper: "Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout." in: Arthritis and rheumatism, Vol. 63, Issue 5, pp. 1322-32, 2011
Sozen, Tsuchiyama, Hasegawa, Suzuki, Jadhav, Nishizawa, Zhang: "Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice." in: Stroke; a journal of cerebral circulation, Vol. 40, Issue 7, pp. 2519-25, 2009
Scott, Ma, Viriyakosol, Terkeltaub, Liu-Bryan: "Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 6370-8, 2006
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