Browse our MAP3K14 Proteins (MAP3K14)

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Mitogen-Activated Protein Kinase Kinase Kinase 14 Proteins (MAP3K14)
On are 9 Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) Proteins from 5 different suppliers available. Additionally we are shipping MAP3K14 Antibodies (132) and many more products for this protein. A total of 153 MAP3K14 products are currently listed.
aly, F23F1.4, F23F1_4, FLH21957, FTDCR1B, HGK, HS, HSNIK, MEKKK4, mitogen-activated protein kinase kinase kinase 14, Nik
list all proteins Gene Name GeneID UniProt
MAP3K14 9020 Q99558
MAP3K14 360640  
MAP3K14 53859 Q9WUL6

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MAP3K14 Proteins (MAP3K14) by Origin

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Human Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) interaction partners

  1. OLFM1 (show OLFM1 Proteins) is a negative regulator of non-canonical NF-kappaB (show NFKB1 Proteins) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (show OLFM1 Proteins) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (show CALR Proteins)) patients.

  2. The expression of OTUD7B (show OTUD7B Proteins) and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (show ODZ1 Proteins) stage. high OTUD7B (show OTUD7B Proteins)/low NIK index can predict an good prognosis.

  3. NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.

  4. This study identified two novel independent loci (MAP3K14 and CARD9 (show CARD9 Proteins)) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.

  5. The forced expression of NDRG2 (show NDRG2 Proteins) in ATL cells down-regulates not only the canonical pathway by inhibiting AKT (show AKT1 Proteins) signaling but also the non-canonical pathway by inducing NF-kappaB (show NFKB1 Proteins)-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A (show PPP2R4 Proteins)

  6. NIK(+) endothelial cells may play an important role in the persistence of synovitis

  7. Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB (show NFKB1 Proteins)-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells.

  8. TWEAK (show TNFSF12 Proteins) induces noncanonical NF-kappaB (show NFKB1 Proteins) signaling and signal-specific regulation of NIK mRNA expression.

  9. by demonstrating a critical role of NIK in mediating NF-kappaB (show NFKB1 Proteins) activation and BAG3 (show BAG3 Proteins) induction upon ST80/Bortezomib cotreatment, our study provides novel insights into mechanisms of resistance to proteotoxic stress in RMS

  10. Loss-of-function mutations in NIK can cause B-cell lymphopenia, hypogammaglobulinemia, impaired ICOSL (show ICOSLG Proteins) expression, and disordered T helper cell and NK cell function.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) interaction partners

  1. this study demonstrates that although NIK (show MAP4K4 Proteins) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells

  2. Using a novel conditional mutant of NIK (show MAP4K4 Proteins), the authors could show in vivo that NIK (show MAP4K4 Proteins) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.

  3. NIK (show MAP4K4 Proteins) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (show TNFRSF1A Proteins)/RIP1 (show RALBP1 Proteins)-dependent cell death independently of the alternative NF-kappaB (show NFKB1 Proteins) pathway.

  4. This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.

  5. results assign NIK (show MAP4K4 Proteins)-induced alternative NF-kappaB (show NFKB1 Proteins) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined

  6. NIK (show MAP4K4 Proteins), and thus probably the noncanonical NF-kappaB (show NFKB1 Proteins) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (show CD8A Proteins) T cells after exposure to licensing stimuli.

  7. Deletion of NIK (show MAP4K4 Proteins) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (show TNFSF13B Proteins).

  8. We identify NIK (show MAP4K4 Proteins) as a critical negative regulator of beta cell function, as pharmacological NIK (show MAP4K4 Proteins) activation results in impaired glucose-stimulated insulin (show INS Proteins) secretion in mouse and human islets.

  9. the NIK (show MAP4K4 Proteins) in thymic stroma may be critically involved in the differentiation of most NKT (show CTSL1 Proteins) cell subsets (although the level of NIK (show MAP4K4 Proteins) dependence may vary among the subsets), and also the NIK (show MAP4K4 Proteins) in NKT (show CTSL1 Proteins)-alphabeta cells may be dispensable for their effector function.

  10. CHIP/TRAF3 (show TRAF3 Proteins)/NIK (show MAP4K4 Proteins) interactions recruit NIK (show MAP4K4 Proteins) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (show MAP4K4 Proteins) at low levels

MAP3K14 Protein Profile

Protein Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Alternative names and synonyms associated with MAP3K14

  • mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
  • mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
  • mitogen-activated protein kinase kinase kinase 14 (Map3k14)
  • mitogen-activated protein kinase kinase kinase 14 (MAPKKK14)
  • aly protein
  • F23F1.4 protein
  • F23F1_4 protein
  • FLH21957 protein
  • FTDCR1B protein
  • HGK protein
  • HS protein
  • HSNIK protein
  • MEKKK4 protein
  • mitogen-activated protein kinase kinase kinase 14 protein
  • Nik protein

Protein level used designations for MAP3K14

NF-kappa-beta-inducing kinase , serine/threonine protein-kinase , serine/threonine-protein kinase NIK , HPK/GCK-like kinase HGK , MAPK/ERK kinase kinase kinase 4 , MEK kinase kinase 4 , Ste20 group protein kinase HGK , hepatocyte progenitor kinase-like/germinal center kinase-like kinase , nck-interacting kinase , NF kappa B-inducing kinase , Nfkb inducing kinase , alymphoplasia , protein kinase

9020 Homo sapiens
9448 Homo sapiens
360640 Rattus norvegicus
817555 Arabidopsis thaliana
53859 Mus musculus
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