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Browse our MAP3K14 Proteins (MAP3K14)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 14 Proteins (MAP3K14)
On are 5 Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) Proteins from 3 different suppliers available. Additionally we are shipping MAP3K14 Antibodies (63) and many more products for this protein. A total of 76 MAP3K14 products are currently listed.
aly, F23F1.4, F23F1_4, FTDCR1B, HS, HSNIK, mitogen-activated protein kinase kinase kinase 14, Nik
list all proteins Gene Name GeneID UniProt
MAP3K14 9020 Q99558
MAP3K14 360640  
MAP3K14 53859 Q9WUL6

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MAP3K14 Proteins (MAP3K14) by Origin

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More Proteins for MAP3K14 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) interaction partners

  1. This study identified two novel independent loci (MAP3K14 and CARD9 (show CARD9 Proteins)) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.

  2. The forced expression of NDRG2 (show NDRG2 Proteins) in ATL cells down-regulates not only the canonical pathway by inhibiting AKT (show AKT1 Proteins) signaling but also the non-canonical pathway by inducing NF-kappaB (show NFKB1 Proteins)-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A (show PPP2R4 Proteins)

  3. NIK(+) endothelial cells may play an important role in the persistence of synovitis

  4. Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB (show NFKB1 Proteins)-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells.

  5. TWEAK (show TNFSF12 Proteins) induces noncanonical NF-kappaB (show NFKB1 Proteins) signaling and signal-specific regulation of NIK mRNA expression.

  6. by demonstrating a critical role of NIK in mediating NF-kappaB (show NFKB1 Proteins) activation and BAG3 (show BAG3 Proteins) induction upon ST80/Bortezomib cotreatment, our study provides novel insights into mechanisms of resistance to proteotoxic stress in RMS

  7. Loss-of-function mutations in NIK can cause B-cell lymphopenia, hypogammaglobulinemia, impaired ICOSL (show ICOSLG Proteins) expression, and disordered T helper cell and NK cell function.

  8. Membrane attack complexes activate noncanonical NF-kappaB (show NFKB1 Proteins) by forming a novel Akt (show AKT1 Proteins)(+)NIK(+) signalosome on Rab5 (show RAB5A Proteins)(+) endosomes.

  9. Authors show that activation of NF-kappaB (show NFKB1 Proteins) by Kaposi's sarcoma-associated herpesvirus K15 (show KRT15 Proteins) protein involves the recruitment of NF-kappaB (show NFKB1 Proteins)-inducing kinase (NIK) and IKK alpha (show CHUK Proteins)/beta to result in the phosphorylation of p65/RelA (show NFkBP65 Proteins) on Ser536.

  10. NIK plays a key role in constitutive NF-kappaB (show NFKB1 Proteins) activation and the progression of ovarian cancer cells

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) interaction partners

  1. NIK (show MAP4K4 Proteins) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (show TNFRSF1A Proteins)/RIP1 (show RALBP1 Proteins)-dependent cell death independently of the alternative NF-kappaB (show NFKB1 Proteins) pathway.

  2. This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.

  3. results assign NIK (show MAP4K4 Proteins)-induced alternative NF-kappaB (show NFKB1 Proteins) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined

  4. NIK (show MAP4K4 Proteins), and thus probably the noncanonical NF-kappaB (show NFKB1 Proteins) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (show CD8A Proteins) T cells after exposure to licensing stimuli.

  5. Deletion of NIK (show MAP4K4 Proteins) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (show TNFSF13B Proteins).

  6. We identify NIK (show MAP4K4 Proteins) as a critical negative regulator of beta cell function, as pharmacological NIK (show MAP4K4 Proteins) activation results in impaired glucose-stimulated insulin (show INS Proteins) secretion in mouse and human islets.

  7. the NIK (show MAP4K4 Proteins) in thymic stroma may be critically involved in the differentiation of most NKT (show CTSL1 Proteins) cell subsets (although the level of NIK (show MAP4K4 Proteins) dependence may vary among the subsets), and also the NIK (show MAP4K4 Proteins) in NKT (show CTSL1 Proteins)-alphabeta cells may be dispensable for their effector function.

  8. CHIP/TRAF3 (show TRAF3 Proteins)/NIK (show MAP4K4 Proteins) interactions recruit NIK (show MAP4K4 Proteins) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (show MAP4K4 Proteins) at low levels

  9. The results suggest a pivotal role of NIK (show MAP4K4 Proteins) in the thymic stroma in establishing self-tolerance by orchestrating cross-talk between medullary thymic epithelial cells and dendritic cells as well as thymocytes.

  10. These studies provide evidence for a role of NF-kappaB (show NFKB1 Proteins)-inducing kinase (NIK (show MAP4K4 Proteins)) and subsequent non-canonical NF-kappaB (show NFKB1 Proteins) signalling in pathological angiogenesis

MAP3K14 Protein Profile

Protein Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Alternative names and synonyms associated with MAP3K14

  • mitogen-activated protein kinase kinase kinase 14 (MAPKKK14)
  • mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
  • mitogen-activated protein kinase kinase kinase 14 (Map3k14)
  • aly protein
  • F23F1.4 protein
  • F23F1_4 protein
  • FTDCR1B protein
  • HS protein
  • HSNIK protein
  • mitogen-activated protein kinase kinase kinase 14 protein
  • Nik protein

Protein level used designations for MAP3K14

NF-kappa-beta-inducing kinase , serine/threonine protein-kinase , serine/threonine-protein kinase NIK , NF kappa B-inducing kinase , Nfkb inducing kinase , alymphoplasia , protein kinase

817555 Arabidopsis thaliana
9020 Homo sapiens
360640 Rattus norvegicus
53859 Mus musculus
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