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|Antigen||TNF Receptor-Associated Factor 3 (TRAF3) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRAF3 antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-TRAF3 AntibodyTarget Details TRAF3 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of TRAF3 protein. (region surrounding Ser289)|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, Mouse, Rat.|
|Purity||> 95 % by SDS-PAGE|
Target Details TRAF3Product Details anti-TRAF3 Antibody Application Details Handling Images back to top
|Alternative Name||TRAF3 / CRAF1 (TRAF3 Antibody Abstract)|
|Background||Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily which includes the Fas antigen and CD40. Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a Synonyms: CAP-1, CAP1, CD40 receptor-associated factor 1, CD40-binding protein, CD40BP, LAP1, LMP1-associated protein, TNF receptor-associated factor 3|
|Molecular Weight||approx. 68 kDa|
|Pathways||NF-kappaB Signaling, Apoptosis, TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-TRAF3 Antibody Target Details TRAF3 Handling Images back to top
Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRAF3 Antibody Target Details TRAF3 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 15 mM Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
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