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Browse our KCNJ5 Proteins (KCNJ5)

Full name:
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 Proteins (KCNJ5)
On are 9 Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 (KCNJ5) Proteins from 4 different suppliers available. Additionally we are shipping KCNJ5 Antibodies (49) and KCNJ5 Kits (4) and many more products for this protein. A total of 68 KCNJ5 products are currently listed.
cir, GIRK4, KATP1, Kir3.4, LQT13, xcir
list all proteins Gene Name GeneID UniProt
KCNJ5 9541 Q86X95
KCNJ5 16521 P48545
KCNJ5 29713 P48548

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KCNJ5 Proteins (KCNJ5) by Origin

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Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 (KCNJ5) interaction partners

  1. The present study demonstrated the high prevalence of somatic KCNJ5 mutations in Korean patients with aldosterone-secreting adenoma. Carriers of somatic KCNJ5 mutations were more likely to be female.

  2. This study confirms the frequency of somatic KCNJ5 mutations in aldosterone production by adenomas.

  3. In aldosterone-producing cells of an in vitro model of hyperaldosteronism GIRK4 does not form functional channels.

  4. Serum adiponectin (show ADIPOQ Proteins) level was an independent predictor of early atherosclerosis in smokers. Nicotine might decrease adiponectin (show ADIPOQ Proteins) in part through altering KATP channels in adipocytes.

  5. Different mutations (KCNJ5, ATP1A1 (show ATP1A1 Proteins), ATP2B3 (show ATP2B3 Proteins), and CACNA1D (show CACNA1D Proteins)) are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified.

  6. GIRK4 immunohistochemistry might be used for initial screening of the somatic mutation status of aldosterone producing adenoma.

  7. Findings in a large Australian cohort show that patients with mutations in KCNJ5 present earlier with the signs and symptoms of primary hyperaldosteronism and benefit from surgical intervention.

  8. KCNJ5 gene mutations are associated with aldosterone-producing adenomas.

  9. Meta-analysis showed that more pronounced hyperaldosteronism, young age, female gender, and larger tumors are the phenotypic features of APA (show ENPEP Proteins) patients with KCNJ5 mutations.[meta-analysis; review]

  10. Besides Na(+)-leak mutations, novel KCNJ5 mutations causing a reduction of surface and total abundance of Kir3.4 are also associated with sporadic aldosterone-producing adenoma.

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 (KCNJ5) interaction partners

  1. These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin (show INS Proteins) secretion.

  2. study establishes the role of f-channels in cardiac automaticity and indicates that arrhythmia related to HCN loss-of-function may be managed by pharmacological or genetic inhibition of GIRK4 channels

  3. Data indicate taht m2R-RGS6 (show RGS6 Proteins)-IKACh pathway sets heart rate variability independently from the autonomic input.

  4. Therefore, the lack of proper functioning of the cardio-protective K(ATP) system in the mdx (show DMD Proteins) cardiomyocytes may be part of the mechanism contributing to development of cardiac disease in dystrophic patients.

  5. Data suggest HL-1 (show ASGR1 Proteins) cells express GIRK1 (show KCNJ3 Proteins)/4 and M2 muscarinic receptors and are a good model to study acetylcholine-activated potassium currents.

  6. Data show that the composition of the Kir3.1 (show KCNJ3 Proteins) and Kir (show GEM Proteins) 3.4 subunits of the G protein-gated potassium channel (show KCNAB2 Proteins) changes during embryonic development.

  7. These data implicate GIRK4-containing channels in signaling crucial to energy homeostasis and body weight.

Pig (Porcine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 (KCNJ5) interaction partners

  1. Blockade of K(ATP) channels further diminished (approximately 45%) the repayment of flow debt (show PLXNB2 Proteins) in lean but not metabolic syndrome swine.

KCNJ5 Protein Profile

Protein Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.

Alternative names and synonyms associated with KCNJ5

  • corepressor interacting with RBPJ, 1 (CIR1)
  • corepressor interacting with RBPJ, 1 (cir1)
  • potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5)
  • potassium inwardly-rectifying channel, subfamily J, member 5 (Kcnj5)
  • cir protein
  • GIRK4 protein
  • KATP1 protein
  • Kir3.4 protein
  • LQT13 protein
  • xcir protein

Protein level used designations for KCNJ5

CBF1 interacting corepressor , CBF1-interacting corepressor , corepressor interacting with RBPJ 1 , recepin , G protein-activated inward rectifier potassium channel 4 , IRK-4 , cardiac ATP-sensitive potassium channel , heart KATP channel , inward rectifier K+ channel KIR3.4 , CIR , GIRK-4 , KATP-1 , cardiac inward rectifier , inward rectifier K(+) channel Kir3.4 , potassium channel, inwardly rectifying subfamily J member 5 , GIRK4 , inward rectifying K channel , potassium inwardly-rectifying channel J5

9541 Homo sapiens
446936 Xenopus laevis
426529 Gallus gallus
3762 Homo sapiens
16521 Mus musculus
29713 Rattus norvegicus
395925 Gallus gallus
489284 Canis lupus familiaris
397448 Sus scrofa
100352473 Oryctolagus cuniculus
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