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BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 (show NOTCH1 Proteins) intracellular domain, preventing the coactivator Mastermind-like1 (MAM1) from binding.
XMam1 has the ability to induce the cell fate into the neurogenic lineage in a Notch (show NOTCH1 Proteins)-independent manner
These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 (show RUNX2 Proteins) and plays a role in bone development.
This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine (show CCL1 Proteins) profiles and may also promote innate and adaptive immune cell infiltration and function.
Maml-mediated Notch (show NOTCH1 Proteins) signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis.
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Data demonstrate that Mesp2 (show Mesp2 Proteins) potently represses Notch (show NOTCH1 Proteins) signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway.
MAML1 is a novel modulator for NF-kappaB (show NFKB1 Proteins) signaling and regulates cellular survival.
There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis.
a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 (show NOTCH1 Proteins) inhibition
MAML1 acts as a coactivator for MEF2C (show MEF2C Proteins) transcription and is essential for proper muscle development
Mam-1 is required to some extent for Notch (show NOTCH1 Proteins)-dependent stages in lymphopoiesis, thus supporting the notion that Mam is an essential component of the canonical Notch (show NOTCH1 Proteins) pathway in mammals.
study identifies that MAML1 is ubiquitinated in the absence of Notch (show NOTCH1 Proteins) signaling to maintain low levels of MAML1 in the cell
In MCF-7 cells p53 (show TP53 Proteins) associates with the Notch (show NOTCH1 Proteins) transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53 (show TP53 Proteins)-MAML1 interaction.
The impact of MAML1 genetic variants to heart rate was discovered.
Data indicate that EpCAM (show EPCAM Proteins), CK19 (show KRT19 Proteins), and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients.
Snail (show SNAI1 Proteins) decreased transcription of Notch1 (show NOTCH1 Proteins) intracellular domain (NICD (show NOTCH1 Proteins)) target genes via competing with MAML1, co-activator, in NICD (show NOTCH1 Proteins) complex.
Authors report that human papillomavirus type 8 E6 subverts NOTCH (show NOTCH1 Proteins) activation during keratinocyte differentiation by inhibiting RBPJ (show RBPJ Proteins)/MAML1 transcriptional activator complexes at NOTCH (show NOTCH1 Proteins) target DNA.
Bioinformatics assessment revealed a correlation between p300 (show EP300 Proteins), EGR1 (show EGR1 Proteins) and MAML1 copy number and mRNA alterations in renal clear cell carcinoma and p300 (show EP300 Proteins), EGR1 (show EGR1 Proteins) and MAML1 gene alterations were associated with increased overall survival.
MAML1 is best known as the co-activator and effector of NOTCH (show NOTCH1 Proteins)-induced transcription, and BPV-1 E6 represses synthetic NOTCH (show NOTCH1 Proteins)-responsive promoters, endogenous NOTCH (show NOTCH1 Proteins)-responsive promoters, and is found in a complex with MAML1 in stably transformed cells
Overexpression of MAML-1 and Twist1 (show TWIST1 Proteins) were significantly associated with lymph node metastasis and the surgical staging of tumor
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
, mastermind-like 1
, mastermind-like protein 1
, mastermind homolog