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Browse our Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) ELISA Kits

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Nuclear Receptor Subfamily 1, Group I, Member 3 ELISA Kits (NR1I3)
On www.antibodies-online.com are 11 Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) ELISA Kits from 5 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group I, Member 3 Antibodies (109) and Nuclear Receptor Subfamily 1, Group I, Member 3 Proteins (13) and many more products for this protein. A total of 146 Nuclear Receptor Subfamily 1, Group I, Member 3 products are currently listed.
Synonyms:
AA209988, AI551208, CAR, CAR-beta, CAR1, Care2, CXR, ESTM32, MB67
list all ELISA KIts Gene Name GeneID UniProt
NR1I3 12355 O35627
NR1I3 65035 Q9QUS1
NR1I3 9970 Q14994

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Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) ELISA Kits by Reactivity

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Pig (Porcine) Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) interaction partners

  1. characterized activity profile of CAR and compared with hCAR (show CXADR ELISA Kits) and mCAR (show CXADR ELISA Kits); related this to structural homology among the 3 orthologues; 5 alternative splice variants identified and sequenced each of which generated a truncated protein product

Mouse (Murine) Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) interaction partners

  1. Combining CAR activation with limited beta-catenin (show CTNNB1 ELISA Kits) activation induces tumorigenesis, and the tumours share a conserved gene expression signature with beta-catenin (show CTNNB1 ELISA Kits)-positive human hepatocellular carcinoma.

  2. Constitutive androstane receptor is the main mediator of liver hypertrophy induced by cyproconazole and fluconazole, but not tebuconazole; constitutive androstane receptor played a crucial role in liver tumor development induced by all three triazoles.

  3. CAR activation decreases miR (show MLXIP ELISA Kits)-122 levels through suppression of HNF4alpha (show HNF4A ELISA Kits) transcriptional activity and indirectly regulates the promitogenic protein cMyc (show MYC ELISA Kits).

  4. The induction of CYP2B by PB or CFA (show TBCA ELISA Kits) was comparable to nuclear CAR levels. CAR nuclear translocation was induced by CFA (show TBCA ELISA Kits) in both rat strains.

  5. The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor beta and contributes to the development of experimental dermal fibrosis.

  6. ubiquitin-proteasomal regulation of CCRP (show DNAJC7 ELISA Kits) and HSP70 (show HSP70 ELISA Kits) are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers

  7. These results suggest that in vivo deletion of CAR resulted in higher bone mass, which appears to be a result from reduced metabolism of testosterone due to down-regulation of Cyp2b.

  8. Studies indicate that phenobarbital binding to EGFR inhibits distal signaling to derepress RACK1-facilitated dephosphorylation of constitutive active androstane receptor (CAR) by PP2A, and activates the transcription of Cyp2B10.

  9. Data indicate that the phosphorylation status of constitutive active androstane receptor (CAR) and EGFR (show EGFR ELISA Kits) in response to phenobarbital and EGF (show EGF ELISA Kits) was confirmed in hepatocytes.

  10. Xenobiotic-induced hepatocyte proliferation mediated by CAR or PPARalpha (show PPARA ELISA Kits) is enhanced by PXR (show NR1I2 ELISA Kits) co-activation despite the fact that PXR (show NR1I2 ELISA Kits) activation alone does not cause the cell proliferation in mouse livers.

Human Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) interaction partners

  1. These results reveal both novel and known targets of hCAR (show CXADR ELISA Kits) and support the role of hCAR (show CXADR ELISA Kits) in maintaining the homeostasis of metabolism and cell proliferation in the liver.

  2. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained : VKORC1 (show VKORC1 ELISA Kits) genotype accounted for 29.6%, CYP2C9 (show CYP2C9 ELISA Kits) genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4alpha (show HNF4A ELISA Kits) (rs2501873/rs3212198) for 1.7%

  3. It is suggested that the functions of PXR (show NR1I2 ELISA Kits), CAR and AhR (show AHR ELISA Kits) may be closely implicated in the pathogeneses of metabolic vascular diseases, such as hyperlipidemia, atherogenesis, and hypertension.

  4. Suggest that PXR (show NR1I2 ELISA Kits) and CAR double humanized mice are more sensitive rifampcin induction of cytochrome P450 (show CYP ELISA Kits) and UDP-glucuronosyltransferases.

  5. PRMT5 (show PRMT5 ELISA Kits) enhances transcriptional activity of constitutive androstane receptor.PRMT5 is a gene-selective co-activator for CAR.

  6. The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor beta and contributes to the development of experimental dermal fibrosis.

  7. Donor CYP3A5 (show CYP3A5 ELISA Kits), NR1I3 gene polymorphisms.

  8. ubiquitin-proteasomal regulation of CCRP (show DNAJC7 ELISA Kits) and HSP70 (show HSP70 ELISA Kits) are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers

  9. The polymorphisms investigated in PPARA (show PPARA ELISA Kits) (rs1800206), RXRA (show RXRA ELISA Kits) (rs11381416), and NR1I2 (show NR1I2 ELISA Kits) (rs1523130) did not influence the lipid-lowering efficacy and safety of statin and our results show the possible influence of NR1I3 genetic variant on the safety of statin.

  10. miR (show MLXIP ELISA Kits)-137 is a crucial regulator of cancer response to doxorubicin treatment

Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) Antigen Profile

Antigen Summary

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3)

  • constitutive androstane receptor (CAR) Elisa Kit
  • constitutive androstane receptor (LOC100346291) Elisa Kit
  • nuclear receptor subfamily 1, group I, member 3 (Nr1i3) Elisa Kit
  • nuclear receptor subfamily 1, group I, member 3 (NR1I3) Elisa Kit
  • AA209988 Elisa Kit
  • AI551208 Elisa Kit
  • CAR Elisa Kit
  • CAR-beta Elisa Kit
  • CAR1 Elisa Kit
  • Care2 Elisa Kit
  • CXR Elisa Kit
  • ESTM32 Elisa Kit
  • MB67 Elisa Kit

Protein level used designations for NR1I3

constitutive androstane receptor , constitutively transactivates RAREs , nuclear receptor subfamily 1 group I member 3 , orphan nuclear receptor MB67 , constitutive androstane receptor NR1I3 , nuclear receptor constitutive active receptor , strain Fischer nuclear receptor (CAR) , constitutive activator of retinoid response , constitutive active receptor , constitutive active response , constitutive androstane nuclear receptor variant 2 , constitutive androstane nuclear receptor variant 3 , constitutive androstane nuclear receptor variant 4 , constitutive androstane nuclear receptor variant 5 , orphan nuclear hormone receptor , xenobiotic receptor

GENE ID SPECIES
654317 Sus scrofa
100346291 Oryctolagus cuniculus
12355 Mus musculus
488653 Canis lupus familiaris
493711 Bos taurus
65035 Rattus norvegicus
9970 Homo sapiens
395439 Gallus gallus
574249 Macaca mulatta
458014 Pan troglodytes
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