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Polymorphisms in a putative enhancer at the 10q21.2 Breast Cancer Risk Locus regulate NRBF2 expression, implicating this gene in the etiology of breast cancer.
Nrbf2 may interact with the Atg14L-containing Beclin 1 (show BECN1 Proteins)-Vps34 (show PIK3C3 Proteins) protein complex to modulate protein-protein interactions within the complex.
NRBF2 regulates macroautophagy as a component of Vps34 (show PIK3C3 Proteins) Complex I.
The activation domain, their small size (COPR1, 26.9 kDa; COPR2, 32.4 kDa), and strict dependence on AF-2 for interaction distinguish COPR1 and COPR2 from the SMRT/NCoR (show NCOR1 Proteins) type of corepressor and may dampen rather than repress NR-mediated gene expression.
These data reveal a key role for NRBF2 in the assembly of the specific Atg14L-Beclin 1-Vps34-Vps15 complex for autophagy induction.
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
comodulator of PPAR and RXR 1
, comodulator of PPAR and RXR 2
, nuclear receptor binding factor-2
, nuclear receptor-binding factor 2