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The expression of progesterone receptor in the uterotubular junction after deep intrauterine insemination with a reduced number of sperm was lower than after conventional artificial insemination and might influence sperm transportation and fertilization.
the digitonin-soluble progesterone binding protein (show PGRMC1 ELISA Kits) has a binding site that differs from that of membrane PR; it is concluded that more than one progesterone receptor is present in porcine spermatozoa.
The expression of mRNAs for ERalpha (show ESR1 ELISA Kits), ERbeta (show ESR2 ELISA Kits) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Data suggest that the classical xPR-1, located at the plasma membrane, mediates reinitiation of the meiotic cell cycle in the X. laevis oocyte through a non-genomic mechanism.
Xenopus laevis progesterone receptor is capable of associating with the plasma membrane and this association is through its ligang-binding domain.
Pgr is widely distributed in all regions of the zebrafish brain.
The localization of Pgr suggests that it mediates progestin regulation of reproductive signaling in the brain, early germ cell proliferation in testis, and ovarian follicular functions, but not final oocyte or sperm maturation.
11 beta-hydroxysteroid dehydrogenase activity stimulated by DHP (show DPYS ELISA Kits) via Pgr
Data suggest that there are no changes in expression or localization patterns for PGR and PGRMC1 (show PGRMC1 ELISA Kits) (progesterone receptor membrane component 2 (show PGRMC2 ELISA Kits)) in endometrium in artificially cycled disease-free animals compared with an endometriosis model.
These results indicate that ptger4b expression is regulated by a genomic mechanism involving Pgr.
progesterone acts via the progesterone receptor to modulate ADAMTS 1 (show ADAMTS1 ELISA Kits) and 4 levels in ovarian cancer cell lines.
The ratios of IGF-I (show IGF1 ELISA Kits)/IGFBP-3 (show IGFBP3 ELISA Kits) were increased in postmenopausal Taiwanese women with breast cancer, irrespective of their ages, ER and PR statuses, and HER2 (show ERBB2 ELISA Kits) expression.
Endometriotic lesions/eutopic endometrium from women with endometriosis are uniform in a PR-A-dominant state. Menstrual efflux of a PR-A-dominant endometrial tissue into the peritoneal cavity may play a role in the pathophysiology of endometriosis.
Expression of seven ERalpha (show ESR1 ELISA Kits) splice variants, total progesterone receptor (PR) and of five PR transcript isoforms was found to be significantly decreased in endometrial cancer
Neural Analyses Validate and Emphasize the Role of Progesterone Receptor in Breast Cancer Progression and Prognosis
Data demonstrated the significance of PR extranuclear signaling through PPD (show HPD ELISA Kits) interactions in EGFR (show EGFR ELISA Kits)-mediated proliferation and signaling in NSCLC.
Rs11571215 in PGR (progesterone receptor) was the SNP most strongly associated with ER- disease.
Decreased PGDH (show HPGD ELISA Kits) expression is associated with increased GR and PRA (show S100A6 ELISA Kits), although decreased PRB (show RB1 ELISA Kits), in chorion during labor.
the MapQuanttrade mark assay, based on mRNA expression assay, provides an objective and quantitative assessment of Estrogen receptor (show ESR1 ELISA Kits), Progesterone receptor and HER2 (show ERBB2 ELISA Kits) status in invasive breast cancer.
These findings underscore the importance of understanding the complex interactions between PR and other regulatory factors, such as Stat3 (show STAT3 ELISA Kits), that contribute to determine the context-dependent transcriptional actions of PR.
expression differences among PGR genotypes in oviduct and uterus and when differences appear during gestation
generated a model to study the consequence of increased Notch (show NOTCH1 ELISA Kits) signaling in female reproduction and provide the first evidence, to our knowledge, that Notch (show NOTCH1 ELISA Kits) signaling can regulate epigenetic modification of the progesterone receptor
Calvarial cells had more potential to differentiate into osteoblasts and displayed more osteogeic markers after the PR expression was ablated from the Mx1+ cells. This indicates that PRs may play a role in the later stages of osteoblast differentiation.
progesterone receptor is a key contributor to the hypoxic ventilatory response in newborn mice
Progesterone receptor rapid and nonclassical transcriptional effects govern breast cancer growth.
PgR expression may play an important role in the maturation of cortical connectivity and sensorimotor
RANKL (show TNFSF11 ELISA Kits) is a direct progesterone receptor (PR) target gene and Stat5a (show STAT5A ELISA Kits) has a novel role as a cofactor in PR-mediated transcriptional signaling in the mammary gland.
Progesterone receptor function may be involved in the development of diabetes mellitus.
Progesterone receptor A stability is mediated by glycogen synthase kinase-3beta in the Brca1-deficient mammary gland.
This study demonstrates PR-mediated dynamic expression of Npl (show NPL ELISA Kits) in the periimplantation uterus and dispensable role of Npl (show NPL ELISA Kits) in uterine function and embryo development.
Data from transgenic mice suggest that balance between isoforms of Pgr is critical for mammary tissue homeostasis; PgrA overexpression leads to increased side branching/multilayered ducts; PgrB overexpression leads to limited ductal growth. [REVIEW]
During early pregnancy mares had the same pattern of progesterone receptor in the endometrium as that reported for other mammals; namely, a loss of progesterone receptor from the endometrial epithelia but continued localization in stromal cells.
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
, progesterone receptor
, nuclear progesterone receptor Pgr
, nuclear receptor subfamily 3 group C member 3
, Nuclear receptor subfamily 3 group C member 3