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Browse our Thyroid Hormone Receptor, beta Proteins (THRB)

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Thyroid Hormone Receptor, beta Proteins (THRB)
On www.antibodies-online.com are 11 Thyroid Hormone Receptor, beta (THRB) Proteins from 6 different suppliers available. Additionally we are shipping Thyroid Hormone Receptor, beta Antibodies (124) and Thyroid Hormone Receptor, beta Kits (8) and many more products for this protein. A total of 152 Thyroid Hormone Receptor, beta products are currently listed.
Synonyms:
C-ERBA-2, C-ERBA-BETA, c-erbAbeta, CTR BETA 2, ERBA2, fj24f03, GRTH, LOC734147, Nr1a2, PRTH, RATT3REC, T3Rbeta, T3rec, T3R[b], THR, THR1, THRB, THRB1, THRB2, TR-BETA, trb, TRbeta, TRbeta1, TR[b]1, wu:fj24f03
list all proteins Gene Name GeneID UniProt
THRB 24831  
THRB 21834 P37242
THRB 7068 P10828

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Thyroid Hormone Receptor, beta Proteins (THRB) by Origin

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More Proteins for Thyroid Hormone Receptor, beta Interaction Partners

Mouse (Murine) Thyroid Hormone Receptor, beta (THRB) interaction partners

  1. In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (show SMAD1 Proteins) signaling.

  2. Data show that TRbeta deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.

  3. Results suggest mutually shared roles for thyroid hormone receptor beta isoforms TRbeta1 and TRbeta2 in cochlear development.

  4. Our findings indicated that synergistic signaling of KRAS(G12D) and TRbetaPV led to increased MYC (show MYC Proteins) expression.

  5. T3 induces FGF21 (show FGF21 Proteins) in cultured hepatocytes and this effect involves direct actions of TRbeta1, which binds a TRE (show TREH Proteins) within intron 2 of FGF21 (show FGF21 Proteins). But T3 induced most gene expression in liver independently of FGF21 (show FGF21 Proteins).

  6. TRbeta acts as a cytoplasmic, phosphotyrosine-dependent scaffold for the p85 (show ECM1 Proteins) regulatory subunit of PI3K and the Src kinase (show CSK Proteins) Lyn (show LYN Proteins) in the absence of thyroid hormone (show PTH Proteins).

  7. TRbeta-related deafness originates outside of hair cells and that TRalpha (show GNAT1 Proteins) and TRbeta play opposing, non-redundant roles in hair cells.

  8. Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII (show NR2F2 Proteins).

  9. these data indicate that interactions between NCoR1 (show NCOR1 Proteins) and TR control a specific pathway involved in regulation of cholesterol metabolism and clearance.

  10. Taken together, the results of this study provide new insights into the mechanisms of transcriptional regulation by TRbeta1 in vivo.

Zebrafish Thyroid Hormone Receptor, beta (THRB) interaction partners

  1. Data suggest that the embryonic to larval transitory phase is characterized by its dependency on the timely synthesis of thyroid hormone (show PTH Proteins) and the concomitant autoinductive increase in thyroid hormone receptor beta mRNA levels.

Human Thyroid Hormone Receptor, beta (THRB) interaction partners

  1. p.H271D mutation associated with resistance thyroid hormone (show PTH Proteins) syndrome

  2. diagnosis was confirmed by direct THRB sequencing that revealed 2 novel mutations: the heterozygous p.Ala317Ser in subject 1 and the heterozygous p.Arg438Pro in subject 2

  3. propose that the mutated C-terminal region of TRbeta1 could function as an "onco-domain"

  4. The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases.

  5. cases suggested that certain RTHbeta mutants such as p.R316C might show very mild syndrome of inappropriate secretion of thyrotropin in spite of having apparent peripheral resistance to thyroid hormone (show PTH Proteins)

  6. Loss of heterozygosity in THRB and its proximal microsatellite markers may play a role in tumorigenesis and development in invasive breast cancer.

  7. Results showed that triple negative breast cancer patients expressed low level of THRB which was associated with poor outcome and enhanced resistance to both docetaxel and doxorubicin treatment.

  8. It is demonstrated in this article that the A234T mutation in the THR (show TRH Proteins)-beta gene can cause the thyroid hormone (show PTH Proteins) resistance syndrome.

  9. data indicated altered mineral metabolism in adults and children with resistance to thyroid hormone (show PTH Proteins) due to mutations in the THRB gene

  10. data demonstrate that TR sumoylation is required for activation of the Wnt (show WNT2 Proteins) canonical signaling pathway during preadipocyte proliferation and enhances the PPARgamma (show PPARG Proteins) signaling that promotes differentiation

Cow (Bovine) Thyroid Hormone Receptor, beta (THRB) interaction partners

  1. Increased expression of mammary TRbeta1 and DIO2 (show DIO2 Proteins), and decreased RXRalpha (show RXRA Proteins), provide a mechanism to increase thyroid hormone (show PTH Proteins) activity within the mammary gland during lactation.

Thyroid Hormone Receptor, beta (THRB) Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Alternative names and synonyms associated with Thyroid Hormone Receptor, beta (THRB)

  • thyroid hormone receptor beta (LOC734147)
  • thyroid hormone receptor beta (thrb)
  • thyroid hormone receptor (ERBA BETA1)
  • thyroid hormone receptor beta (Thrb)
  • thyroid hormone receptor, beta (THRB)
  • C-ERBA-2 protein
  • C-ERBA-BETA protein
  • c-erbAbeta protein
  • CTR BETA 2 protein
  • ERBA2 protein
  • fj24f03 protein
  • GRTH protein
  • LOC734147 protein
  • Nr1a2 protein
  • PRTH protein
  • RATT3REC protein
  • T3Rbeta protein
  • T3rec protein
  • T3R[b] protein
  • THR protein
  • THR1 protein
  • THRB protein
  • THRB1 protein
  • THRB2 protein
  • TR-BETA protein
  • trb protein
  • TRbeta protein
  • TRbeta1 protein
  • TR[b]1 protein
  • wu:fj24f03 protein

Protein level used designations for THRB

thyroid hormone receptor beta , nuclear receptor subfamily 1 group A member 2 , thyroid hormone receptor beta isoform , TRbeta2Delta , c-erbA-2 , thyroid hormone receptor beta 3 , thyroid hormone receptor beta2delta , thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2) , TR beta , c-erbA-beta , TRbeta1 , thyroid hormone receptor beta 1 , thyroid hormone receptor beta 2 , thyroid hormone receptor beta-1 , oncogene ERBA2 , thyroid hormone nuclear receptor beta variant 1 , thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) , thyroid hormone receptor beta2 , beta-thyroid hormone receptor

GENE ID SPECIES
734147 Xenopus (Silurana) tropicalis
100049254 Oryzias latipes
100136934 Salmo salar
443445 Ovis aries
24831 Rattus norvegicus
21834 Mus musculus
30607 Danio rerio
7068 Homo sapiens
100303763 Oryctolagus cuniculus
403599 Canis lupus familiaris
788329 Bos taurus
396431 Gallus gallus
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