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study characterized for the first time the human NME5 promoter which is controlled by Sp1 transcription factor (show SP1 Proteins) in pancreatic cancer
found that Nm23-H5 and NDP (show NDP Proteins) kinases A and B are differently distributed in spermatids and mature spermatozoa and could therefore be involved at various levels of sperm differentiation and function
Situs inversus, hydrocephalus, suppurative rhinosinusitis,and sperm flagellar defects in Nme5 null mice are indicative of defective ciliogenesis
nm23-M5 gene plays an important role in late spermiogenesis by elevating the ability of late-stage spermatids to eliminate reactive oxygen species
results reveal that expression of Nm23-M5 plays a critical role in spermiogenesis by increasing the cellular levels of GPX-5 to eliminate reactive oxygen species
Nme5 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).
, NDK-H 5
, NDP kinase homolog 5
, inhibitor of p53-induced apoptosis-beta
, non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
, nucleoside diphosphate kinase homolog 5
, radial spoke 23 homolog
, testis-specific nm23 homolog
, expressed in non-metastatic cells 5