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Browse our anti-MDM2 (MDM2) Antibodies

Full name:
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) Antibodies (MDM2)
On www.antibodies-online.com are 376 Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Antibodies from 26 different suppliers available. Additionally we are shipping MDM2 Proteins (21) and MDM2 Kits (10) and many more products for this protein. A total of 443 MDM2 products are currently listed.
Synonyms:
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834
list all antibodies Gene Name GeneID UniProt
MDM2 4193 Q00987
MDM2 314856  
MDM2 17246 P23804

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Top referenced anti-MDM2 Antibodies

  1. Human Polyclonal MDM2 Primary Antibody for EIA, IHC (p) - ABIN356776 : Burch, Scott, Pohler, Meek, Hupp: Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. in Journal of molecular biology 2004 (PubMed)
    Show all 5 references for ABIN356776

  2. Human Polyclonal MDM2 Primary Antibody for EIA, IHC (p) - ABIN4620532 : Schon, Friedler, Freund, Fersht: Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes. in Journal of molecular biology 2004 (PubMed)
    Show all 5 references for ABIN4620532

  3. Human Polyclonal MDM2 Primary Antibody for EIA - ABIN358421 : Mantesso, Loducca, Bendit, Garicochea, Nunes, de Araújo: Mdm2 mRNA expression in salivary gland tumour cell lines. in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2004 (PubMed)
    Show all 5 references for ABIN358421

  4. Human Polyclonal MDM2 Primary Antibody for IHC (p), WB - ABIN388068 : Xia, Paik, Li: p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. in Cancer research 2004 (PubMed)
    Show all 3 references for ABIN388068

  5. Human Monoclonal MDM2 Primary Antibody for IHC (fro), IHC (p) - ABIN180331 : Gueven, Becherel, Birrell, Chen, DelSal, Carney, Grattan-Smith, Lavin: Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. in Cancer research 2006 (PubMed)
    Show all 3 references for ABIN180331

  6. Human Polyclonal MDM2 Primary Antibody for DB, EIA - ABIN358505 : Balass, Kalef, Maya, Wilder, Oren, Katchalski-Katzir: Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation. in Peptides 2002 (PubMed)
    Show all 3 references for ABIN358505

  7. Human Polyclonal MDM2 Primary Antibody for IF, IHC (p) - ABIN388067 : Lei, Velez, Kazlauskas: Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. in Molecular and cellular biology 2011 (PubMed)
    Show all 2 references for ABIN388067

  8. Human Polyclonal MDM2 Primary Antibody for ELISA, WB - ABIN185508 : Bond, Hu, Bond, Robins, Lutzker, Arva, Bargonetti, Bartel, Taubert, Wuerl, Onel, Yip, Hwang, Strong, Lozano, Levine: A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. in Cell 2004 (PubMed)

More Antibodies against MDM2 Interaction Partners

Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Antibodies)/Mdm2-Mdm4 (show MDM4 Antibodies) via a RING domain-mediated biochemical mechanism.

  2. Tat (show TAT Antibodies) exploited the cellular HDM2 (human double minute 2 protein) ubiquitin ligase to accelerate IRF-1 (show IRF1 Antibodies) proteasome-mediated degradation, resulting in a quenching of IRF-1 (show IRF1 Antibodies) transcriptional activity during HIV-1 infection.

  3. Data show that long noncoding RNAs lnc00462717 direct target MDM2 protein and regulate MAPK (show MAPK1 Antibodies) relevant pathway expression.

  4. TLP (show TBPL1 Antibodies) Prevents p53 (show TP53 Antibodies) Degradation through Disrupting the p53 (show TP53 Antibodies)-MDM2 Interaction.

  5. MDM2 T309G polymorphism is associated with risk and prognosis of lung cancer. TT or T genotype may be associated with the reduced risk of lung cancer, especially in Asians (Meta-Analysis)

  6. NF2 (show NF2 Antibodies) regulates the interaction of FAK (show PTK2 Antibodies)-p53 (show TP53 Antibodies) and MDM2-p53 (show TP53 Antibodies).

  7. Report up-regulation of TP53 (show TP53 Antibodies)/MDM2 signaling pathway in breast carcinomas.

  8. Expressions of COX-2 (show COX2 Antibodies), p53 (show TP53 Antibodies), and MDM2 increased with oral submucous fibrosis progression.

  9. LRRC8A (show LRRC8A Antibodies) is an essential regulator of cisplatin induced p53 (show TP53 Antibodies) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2, as well as activation of caspase-9 (show CASP9 Antibodies) and -3 in tumor cell lines.

  10. These results indicate that p53 (show TP53 Antibodies)-independent upregulation of MDM2 by increasing selected clones may lead to oncogenesis.

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (show TP53 Antibodies)-dependent apoptosis of Theileria parva (show PARVA Antibodies)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (show PARVA Antibodies), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (show PARVA Antibodies)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (show MDM4 Antibodies) caused dramatic accumulation of mutant p53 protein (show TP53 Antibodies).

  2. Together with p53 (show TP53 Antibodies), provides an experimental model for characterizing drugs and genes that affect p53 (show TP53 Antibodies) signaling.

  3. Data show that liver-specific expression of p53 (show TP53 Antibodies)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Antibodies)/Mdm2-Mdm4 (show MDM4 Antibodies) via a RING domain-mediated biochemical mechanism.

  2. both MDM2 and MDMX (show MDM4 Antibodies) deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 Antibodies), verifying the crucial role of the MDM2 and/or MDMX (show MDM4 Antibodies) in regulating p53 (show TP53 Antibodies) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  3. Vif (show BTG1 Antibodies) stabilization by CBFbeta (show CBFB Antibodies) is mainly caused by impairing MDM2-mediated degradation.

  4. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  5. we failed to detect any increase in p53 (show TP53 Antibodies) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 Antibodies)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (show MDM4 Antibodies), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  6. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 Antibodies).

  7. Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 Antibodies) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.

  8. These findings elucidate a critical role of Mdm2-p53 (show TP53 Antibodies)-Nedd4-2 (show NEDD4L Antibodies) signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  9. These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for Triple-negative breast cancers .

  10. there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 (show TP53 Antibodies) axis which is important in normal hematopoiesis.

MDM2 Antigen Profile

Antigen Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) antibody
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2) antibody
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2) antibody
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2) antibody
  • p53 E3 ubiquitin protein ligase (Mdm2) antibody
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2) antibody
  • transformed mouse 3T3 cell double minute 2 (Mdm2) antibody
  • 1700007J15Rik antibody
  • AA415488 antibody
  • ACTFS antibody
  • hdm2 antibody
  • HDMX antibody
  • Mdm-2 antibody
  • zgc:109834 antibody

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

GENE ID SPECIES
4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
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