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MDM4-binding Protein Antibodies

(Mdm4-binding Protein (MDM4))
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
MDM4-binding Protein antibody  (AA 1-490) MDM4-binding Protein antibody  (AA 1-490) MDM4-binding Protein antibody (AA 1-490) (ABIN948119)

MDM4 Reactivity: Human IF, IP, WB Host: Rabbit Polyclonal unconjugated

MDM4-binding Protein antibody MDM4-binding Protein antibody MDM4-binding Protein antibody (ABIN969282)

MDM4 Reactivity: Human ICC, IHC, ELISA, WB Host: Mouse Monoclonal 2D10F4 unconjugated

MDM4-binding Protein antibody MDM4-binding Protein antibody MDM4-binding Protein antibody (ABIN1108193)

MDM4 Reactivity: Human EIA, IF, IHC (p), WB Host: Mouse Monoclonal 2D10F4 unconjugated

MDM4-binding Protein Antibodies by Reactivity

Find MDM4-binding Protein Antibodies for a variety of species such as anti-Human MDM4-binding Protein, anti-Mouse MDM4-binding Protein, anti-Rat MDM4-binding Protein. The species listed below are among those available. Click on a link to go to the corresponding products.

MDM4-binding Protein Antibodies by Application

Find MDM4-binding Protein Antibodies validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

MDM4-binding Protein Antibodies by Host

Find MDM4-binding Protein Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

MDM4-binding Protein Antibodies by Binding Specificity

Find MDM4-binding Protein Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

MDM4-binding Protein Antibodies by Clonality

Find available monoclonal or polyclonal MDM4-binding Protein Antibodies. Click on a link to go to the corresponding products.

MDM4-binding Protein Antibodies by Clone

Find MDM4-binding Protein Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

MDM4-binding Protein Antibodies by Conjugate

Find MDM4-binding Protein Antibodies with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular MDM4-binding Protein Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC, IHC (p), WB
Validations
  • (4)
Cat. No. ABIN1499354
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Horse, Human, Pig, Rabbit
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN2792185
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN6263182
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (1)
  • (2)
Cat. No. ABIN517808
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN574023
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (2)
Cat. No. ABIN7138576
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC (p), WB
Validations
  • (2)
Cat. No. ABIN3044527
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, ELISA, WB
Validations
  • (2)
Cat. No. ABIN1532152
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application IP, ELISA, WB
Validations
  • (2)
  • (1)
Cat. No. ABIN3201009
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Human, Pig, Rabbit
Application IHC, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN6747187
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN7165802
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (1)
Cat. No. ABIN3185504
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Human
Application WB
Validations
  • (1)
Cat. No. ABIN926007
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN2442622
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (1)
Cat. No. ABIN872900
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our MDM4-binding Protein Antibodies

Karki, Putra, Kim, Laquaglia, Perez-Atayde, Sadri-Vakili, Vakili: "MDM4 expression in fibrolamellar hepatocellular carcinoma." in: Oncology reports, (2019) (PubMed).

Mancini, Teveroni, Di Conza, Monteleone, Arisi, Pellegrino, Buttarelli, Pieroni, DOnofrio, Urbani, Pontecorvi, Mazzone, Moretti: "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability." in: Molecular cancer, Vol. 16, Issue 1, pp. 55, (2017) (PubMed).

Mancini, Pieroni, Monteleone, Lucà, Fici, Luca, Urbani, Xiong, Soddu, Masetti, Lozano, Pontecorvi, Moretti: "MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response." in: Oncogene, (2015) (PubMed).

Elgohary, Pellegrino, Neumann, Elzawahry, Saber, Zeeneldin, Geffers, Ehemann, Schemmer, Schirmacher, Longerich: "Protumorigenic role of Timeless in hepatocellular carcinoma." in: International journal of oncology, Vol. 46, Issue 2, pp. 597-606, (2014) (PubMed).

Jacob, OBrien, Singh, Comiskey, Littleton, Mohammad, Gladman, Widmann, Jeyaraj, Bolinger, Anderson, Barkauskas, Boris-Lawrie, Chandler: "Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 9, pp. 1049-63, (2013) (PubMed).

Biderman, Poyurovsky, Assia, Manley, Prives: "MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress." in: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1214-25, (2012) (PubMed).

Lee, Jin, He, Zeng, Wang, Wahl, Lu: "Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20898-903, (2012) (PubMed).

Henze, Mühlenberg, Simon, Grabellus, Rubin, Taeger, Schuler, Treckmann, Debiec-Rychter, Taguchi, Fletcher, Bauer: "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors." in: PLoS ONE, Vol. 7, Issue 5, pp. e37776, (2012) (PubMed).

Leventaki, Rodic, Tripp, Bayerl, Perkins, Barnette, Schiffman, Miles: "TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases." in: British journal of haematology, Vol. 158, Issue 6, pp. 763-71, (2012) (PubMed).

Mandke, Wyatt, Fraser, Bates, Berberich, Markey: "MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame." in: PLoS ONE, Vol. 7, Issue 8, pp. e42034, (2012) (PubMed).

Aliases for MDM4-binding Protein Antibodies

MDM4, p53 regulator S homeolog (mdm4.S) Antibodies
MDM4, p53 regulator (MDM4) Antibodies
MDM4, p53 regulator (Mdm4) Antibodies
MDM4, p53 regulator (mdm4) Antibodies
transformed mouse 3T3 cell double minute 4 (Mdm4) Antibodies
4933417N07Rik Antibodies
AA414968 Antibodies
AL023055 Antibodies
AU018793 Antibodies
AU021806 Antibodies
C85810 Antibodies
HDMX Antibodies
mdmx Antibodies
MDMX Antibodies
Mdmx Antibodies
MRP1 Antibodies
wu:fa09h09 Antibodies
wu:fi33d10 Antibodies
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