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Therefore, the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
the c-FLIP (show CFLAR ELISA Kits) and NOXA/Mcl-1 (show MCL1 ELISA Kits) axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells
Noxa is involved in X-ray-induced lung injury.
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and acts synergistically with antimicrotubule drugs.
knockdown of MCL-1 (show MCL1 ELISA Kits) in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells
high levels of miR21 expression may induce gastric cancer migration and invasion via the downregulation of Noxa expression
Inhibition of SIRT1 (show SIRT1 ELISA Kits) could induce the Noxa expression in A549/DDP (show TIMM8A ELISA Kits) cells.
Fluorizoline bind to prohibitin (show PHB ELISA Kits), inducing mitochondrial apoptotic pathway through NOXA and BIM (show BCL2L11 ELISA Kits) upregulation.
Noxa demethylation has a role in Bortezomib resistance in mantle cell lymphoma
SATB1 (show SATB1 ELISA Kits) as a Dual Regulator of Anti-Apoptotic BCL2 (show BCL2 ELISA Kits) and Pro-Apoptotic NOXA Genes
ALK (show ALK ELISA Kits)-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax (show BAX ELISA Kits) from Bcl-2 (show BCL2 ELISA Kits).
In vivo upregulation of noxa was reduced by pifithrin-alpha, suggesting transcription may be partly p53 (show TP53 ELISA Kits)-dependent.The present findings indicate Noxa does not serve as a proapoptotic BH3-only protein (show BAD ELISA Kits) during seizure-induced neuronal death in vivo
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2 (show SALL2 ELISA Kits)/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Our data demonstrate that ES cells are uniquely sensitive to CDK1 (show CDK1 ELISA Kits) inhibition via a p53 (show TP53 ELISA Kits)/NOXA/MCL1 (show MCL1 ELISA Kits) pathway.
Overall, these data reveal a Noxa-mediated signaling pathway that couples lysosomal membrane permeabilization with mitochondrial outer membrane permeabilization and ultimate apoptosis during oxidative stress.
by preventing the consumption of IL-15 (show IL15 ELISA Kits), Bim (show BCL2L11 ELISA Kits) limits the role of Noxa and Puma (show BBC3 ELISA Kits) in causing the death of effector cells with less memory potential.
Induction of noxa does not influence ischemic neuronal injury.
the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
Noxa controls expansion of erythroid precursors and RBC (show CACNA1C ELISA Kits) production in vivo under conditions of induced anemia.
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
phorbol-12-myristate-13-acetate-induced protein 1
, PMA-induced protein 1
, adult T cell leukemia-derived PMA-responsive
, immediate-early-response protein APR
, protein Noxa