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Browse our anti-p53 (TP53) Antibodies

Full name:
anti-Tumor Protein P53 Antibodies (TP53)
On are 1863 Tumor Protein P53 (TP53) Antibodies from 48 different suppliers available. Additionally we are shipping p53 Kits (128) and p53 Proteins (78) and many more products for this protein. A total of 2232 p53 products are currently listed.
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919

All available anti-p53 Antibodies

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Top referenced anti-p53 Antibodies

  1. Human Monoclonal p53 Primary Antibody for IHC (f), IHC (fro) - ABIN967416 : Cheng, Yee, Yeargin, Friedmann, Haas: Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. in Cancer research 1992 (PubMed)
    Show all 11 references for ABIN967416

  2. Human Polyclonal p53 Primary Antibody for IF, IHC (p) - ABIN390204 : Blanchette, Cheng, Yan, Ketner, Ornelles, Dobner, Conaway, Conaway, Branton: Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for ABIN390204

  3. Human Monoclonal p53 Primary Antibody for IHC (fro), IF - ABIN1108553 : Isobe, Emanuel, Givol, Oren, Croce: Localization of gene for human p53 tumour antigen to band 17p13. in Nature 1986 (PubMed)
    Show all 2 references for ABIN1108553

  4. Human Polyclonal p53 Primary Antibody for IHC, ELISA - ABIN1531939 : Lohrum, Scheidtmann: Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes. in Oncogene 1997 (PubMed)

  5. Cow (Bovine) Polyclonal p53 Primary Antibody for WB - ABIN2779979 : Rotter, Wolf, Pravtcheva, Ruddle: Chromosomal assignment of the murine gene encoding the transformation-related protein p53. in Molecular and cellular biology 1984 (PubMed)

  6. Human Polyclonal p53 Primary Antibody for ELISA, WB - ABIN1531937 : Kyriakis, Banerjee, Nikolakaki, Dai, Rubie, Ahmad, Avruch, Woodgett: The stress-activated protein kinase subfamily of c-Jun kinases. in Nature 1994 (PubMed)

  7. Cow (Bovine) Polyclonal p53 Primary Antibody for WB - ABIN2777951 : Boehme, Kulikov, Blattner: p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against p53 Interaction Partners

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

  1. Microwave radiation leads to oxidative/nitrosative stress induced p53-dependent/independent activation of hippocampal neuronal and nonneuronal apoptosis associated with spatial memory loss.

  2. These studies support a direct relationship between p53 mutations and GLDC (show GLDC Antibodies) expression in B cell lymphoma.

  3. ISCU (show ISCU Antibodies) expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 mutation.

  4. Hyperactive mTOR (show FRAP1 Antibodies) signaling combined with loss of p53 in mice induces tumors similar to human acinar cell carcinoma.

  5. gene deletion in Bcl-2 (show BCL2 Antibodies)-/- mice inhibits apoptosis induction in spleen and hair follicle melanocytes and keratinocytes, but not in kidney

  6. The expression of Trp53 was increased in tumor transplants undergoing oncogene (show RAB1A Antibodies)-induced senescence. Trp53 inactivation reversed this.

  7. Mild p53 activation in the myeloid linage attenuates tumor development and suppresses alternative macrophage polarization together with c-MYC (show MYC Antibodies) downregulation.

  8. A nonsynonymous single-nucleotide polymorphism at codon 47 in TP53 (S47) exhibits a modest decrease in apoptosis in response to most genotoxic stresses compared with wild-type p53 but exhibits a significant defect in cell death induced by cisplatin.

  9. inhibition of UBF (show UBTF Antibodies) function is a major factor in the cytotoxicity of cisplatin; its depletion selectively induces p53-independent apoptotic death in transformed cells

  10. There is a p53 dependent downregulation of Fanc genes in Fanconi Anaemia.

Human Tumor Protein P53 (TP53) interaction partners

  1. Findings suggest that silibinin's efficacy against UVB-induced photodamage is primarily by inhibiting nucleotide excision repair (NER (show NR1H2 Antibodies)) and tumor protein p53.

  2. TRIM65 is a potential oncogenic protein, highly likely through p53 inactivation

  3. loss of Che-1 (show BCHE Antibodies) inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53

  4. that miR-4516 mediated down-regulation of UBE2N promotes p53 nuclear translocation and pro-apoptotic activity of PUVA is independent of IRF3 but is mediated by the RIG-I in a p53 and NFkappaB dependent manner

  5. Point mutations in TP53 but not in p15(Ink4b (show CDKN2B Antibodies)) and p16(Ink4a (show CDKN2A Antibodies)) genes represent poor prognosis factors in acute adult T cell leukemia/lymphoma

  6. p53 level is diminished during replicative senescence and oncogene (show RAB1A Antibodies)-induced senescence, and that such diminution is associated with H3 deacetylation at the p53 promoter. The reduced intracellular p53 level in keratinocytes of the elderly could be a contributing factor for more frequent development of epithelial cancer in the elderly because of the loss of genomic integrity of cells

  7. ATRX (show ATRX Antibodies) loss may predict better clinical outcome in astrocytoma patients with p53 overexpression as compared to patients with wild-type ATRX (show ATRX Antibodies)

  8. R337H mutation of the TP53 gene has significant predictive and prognostic value and is associated with tumorigenesis of the adrenal cortex.

  9. DNA damage induced necrosis through a PARP1 (show PARP1 Antibodies)-dependent and p53-independent pathway.

  10. Studies indicate that Programmed Cell Death 5 (PDCD5 (show PDCD5 Antibodies)) interacts with the tumor protein p53 (p53) pathway to promote cell apoptosis.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

  1. SIRT1 (show SIRT1 Antibodies), p53 and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  2. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  3. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Antibodies)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Antibodies)).

  4. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Antibodies) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  5. role of transcription factor p53 and the metabolic hormone leptin (show LEP Antibodies), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  6. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  7. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Antibodies) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  8. Suppressive effect of FSH (show BRD2 Antibodies) and LH on p53 expression and caspase-3 (show CASP3 Antibodies) activity with parallel increase in bcl-2 (show BCL2 Antibodies) expression and increased P production was observed.

  9. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

  10. exogenous in vivo NO treatment seems to preserve VSMC from mitochondrial-dependent apoptosis and drive cells to quiescence through p53 increase

Rabbit Tumor Protein P53 (TP53) interaction partners

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (show MAPK14 Antibodies) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Antibodies) plays a role by way of stimulating NF-kappaB (show NFKB1 Antibodies), p53 and caspase-3 (show CASP3 Antibodies) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Antibodies) proteins.

  4. Chronically activated, monomeric PDGFRA (show PDGFRA Antibodies) induced prolonged activation of Akt (show AKT1 Antibodies) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Antibodies), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A (show DNMT3A Antibodies) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (show AKT1 Antibodies) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

  1. Expression of p53 and Ki67 (show MKI67 Antibodies) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) interaction partners

  1. C/ebpalpha (show CEBPA Antibodies) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (show KLF8 Antibodies), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (show MDM2 Antibodies) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) Antigen Profile

Antigen Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758) antibody
  • tumor protein p53 (TP53) antibody
  • tumor supressor p53 (tp53) antibody
  • p53 tumor suppressor (P53) antibody
  • transformation related protein 53 (Trp53) antibody
  • transformation related protein 53, pseudogene (Trp53-ps) antibody
  • trichoplein, keratin filament binding (TCHP) antibody
  • tumor protein p53 (Tp53) antibody
  • tumor protein p53 (tp53) antibody
  • Wistar clone pR53P1 p53 pseudogene (p53-ps) antibody
  • bbl antibody
  • BCC7 antibody
  • bfy antibody
  • bhy antibody
  • brp53 antibody
  • drp53 antibody
  • etID22686.5 antibody
  • fb40d06 antibody
  • LFS1 antibody
  • p44 antibody
  • P53 antibody
  • Tp53 antibody
  • TpMs antibody
  • Trp53 antibody
  • wu:fb40d06 antibody
  • Xp53 antibody
  • zgc:111919 antibody

Protein level used designations for TP53

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
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