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Overexpression of ZnT7 is accompanied by activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway and inhibiting HG-induced apoptosis.
Intracellular transporters such as ZnT7, influence the transcellular movement of zinc across the enterocyte
hZnT-7 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells.
Data show that ZNT7 is extensively present in the Abeta (show APP Proteins)-positive plaques in the cortex of human AD brains.
The results demonstrated that ZnT7 gene silencing downregulated the expression of StAR, P450scc (show CYP11A1 Proteins) and 3beta-HSD (show HAL Proteins) as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells.
A role for ZnT7 in adipocyte lipogenesis: reduction of Znt7 expression affects lipid accumulation in adipocytes.
In Znt7 knockout mice, the body weight and fat deposit was significantly linked to a locus on chromosome 7 ranging from 64.3 to 78.3 Mb.
ZnT7 promotes cell survival via two distinct signaling pathways involving activation of the PI3K/Akt (show AKT1 Proteins)-mediated survival pathway and activation of MAPK/ERK (show MAPK1 Proteins) pathway.
Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin (show INS Proteins) resistance
A null-mutation of the Znt7 gene accelerates prostate tumor formation in TRAMP (show DPT Proteins) mice.
ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded protein response as did the wild-type cells cultured under a zinc-deficient condition, revealing that both complexes play a role in homeostatic maintenance of secretory pathway function
These observations strongly suggest that ZnT7 may play critical roles in retinal zinc homeostasis and that chelatable zinc pools may have multiple functions in the retina.
ZNT7 has essential functions in dietary zinc absorption and in regulation of body adiposity.
These observations support the notion that ZnT7 may participate in zinc transport, storage, and incorporation of zinc into zinc-binding proteins in the Golgi apparatus of mouse SCG (show KPNB1 Proteins) neurons.
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004
solute carrier family 30 member 7
, zinc transporter 7
, zinc transporter 7-B
, solute carrier family 30 member 7-B
, solute carrier family 30 (zinc transporter), member 7
, zinc transporter like 2
, zinc transporter ZnT-7
, znt-like transporter 2