Activating Transcription Factor 6 beta (ATF6B) (Middle Region) Peptide
ATF6B
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ATF6B products
- ATF6B (Activating Transcription Factor 6 beta (ATF6B))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CREBL1 antibody (Catalog #: ARP31562_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ATF6B (Activating Transcription Factor 6 beta (ATF6B))
- Synonyms
- CREBL1 Peptide, CREB-RP Peptide, G13 Peptide, AA617266 Peptide, ATF6beta Peptide, Creb-rp Peptide, Crebl1 Peptide, activating transcription factor 6 beta Peptide, cyclic AMP-dependent transcription factor ATF-6 beta Peptide, ATF6B Peptide, LOC745411 Peptide, Atf6b Peptide
- Background
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ATF6B(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6B is normally found in the membrane of the endoplasmic reticulum, however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CREB-RP, FLJ10066, G13, CREBL1
Protein Interaction Partner: HCVgp1,ATF6,MBTPS1,MBTPS2,NFYC,PHOX2A,ATF6,NFYA,NFYC
Protein Size: 703 - Molecular Weight
- 77 kDa
- Gene ID
- 1388
- NCBI Accession
- NM_004381, NP_004372
- UniProt
- Q99941
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