E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3) Peptide
ELF3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ELF3 products
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ELF3 antibody (Catalog #: ARP31639_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Synonyms
- ert Peptide, esx Peptide, epr-1 Peptide, ese-1 Peptide, ESE-1 Peptide, ESX Peptide, jen Peptide, EPR-1 Peptide, ERT Peptide, E74 like ETS transcription factor 3 Peptide, E74-like factor 3 Peptide, elf3 Peptide, Elf3 Peptide, ELF3 Peptide
- Background
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ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Alias Symbols: EPR-1, ERT, ESE-1, ESX
Protein Interaction Partner: CREBBP,EGFR,EP300,EPS15,JUN,MED23,MYC,NFKB1,TAF9,ATIC,CALR,DDX3X,EEF1D,EHF,ERBB2,GANAB,ISG15,JAK1,KRT31,KRT82,MED23,NFKB1,P4HB,TARS
Protein Size: 371 - Molecular Weight
- 41 kDa
- Gene ID
- 1999
- NCBI Accession
- NM_004433, NP_004424
- UniProt
- P78545
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