E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3) (Middle Region) Peptide
ELF3
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all ELF3 products
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Protein Region
- Middle Region
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TATPQSSHAS DSGGSDVDLD LTESKVFPRD GFPDYKKGEP KHGKRKRGRP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Elf3 Antibody(ARP36847_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Synonyms
- ert Peptide, esx Peptide, epr-1 Peptide, ese-1 Peptide, ESE-1 Peptide, ESX Peptide, jen Peptide, EPR-1 Peptide, ERT Peptide, E74 like ETS transcription factor 3 Peptide, E74-like factor 3 Peptide, elf3 Peptide, Elf3 Peptide, ELF3 Peptide
- Background
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Elf3 is a transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Elf3 acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter.Elf3 also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Elf3 represses KRT4 promoter activity.Elf3 is involved in mediating vascular inflammation. Elf3 may play an important role in epithelial cell differentiation and tumorigenesis. Elf3 may be a critical downstream effector of the ERBB2 signaling pathway. Elf3 may be associated with mammary gland development and involution. Elf3 plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
Alias Symbols: ESE-1, ESX, jen
Protein Size: 371 - Molecular Weight
- 42 kDa
- Gene ID
- 13710
- NCBI Accession
- NM_007921, NP_031947
- UniProt
- Q3UPW2
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