Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) (Middle Region) Peptide
GCLC
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all GCLC products
- GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Sequence
- RISKSRYDSI DSYLSKCGEK YNDIDLTIDK EIYEQLLQEG IDHLLAQHVA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GCLC Antibody(ARP54577_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
- Synonyms
- GCLC Peptide, gclc Peptide, MGC146287 Peptide, 2259 Peptide, CG2259 Peptide, DmGCLC Peptide, DmGCS Peptide, DmGCSh Peptide, Dmel\\CG2259 Peptide, GCL Peptide, GCLc Peptide, GCSh Peptide, Gcs Peptide, Gcsh Peptide, DDBDRAFT_0186120 Peptide, DDBDRAFT_0231403 Peptide, DDB_0186120 Peptide, DDB_0231403 Peptide, GCS Peptide, GLCL Peptide, GLCLC Peptide, D9Wsu168e Peptide, GLCL-H Peptide, Ggcs-hs Peptide, Glclc Peptide, cb1049 Peptide, fe36e11 Peptide, wu:fe36e11 Peptide, glutamate-cysteine ligase catalytic subunit Peptide, glutamate-cysteine ligase, catalytic subunit Peptide, Glutamate-cysteine ligase catalytic subunit Peptide, gamma glutamylcysteine synthetase Peptide, glutamate-cysteine ligase, catalytic subunit L homeolog Peptide, glutamate-cysteine ligase, catalytic subunit S homeolog Peptide, gamma-glutamylcysteine synthetase Peptide, GCLC Peptide, gclc Peptide, Gclc Peptide, LbGCS Peptide, gcsA Peptide, gclc.L Peptide, gclc.S Peptide, GSH1 Peptide
- Background
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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. GCLC is the catalytic subunit of 637 amino acids with a calculated molecular weight of 72.773 kDa. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Alias Symbols: GCL, GCS, GLCL, GLCLC
Protein Size: 637 - Molecular Weight
- 73 kDa
- Gene ID
- 2729
- NCBI Accession
- NM_001498, NP_001489
- UniProt
- P48506
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