Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) (Middle Region) Peptide

Details for Product No. ABIN977333, Supplier: Log in to see
Protein Name
  • GCLC
  • gclc
  • MGC146287
  • 2259
  • CG2259
  • DmGCLC
  • DmGCS
  • DmGCSh
  • Dmel\\CG2259
  • GCL
  • GCLc
  • GCSh
  • Gcs
  • Gcsh
  • DDBDRAFT_0186120
  • DDBDRAFT_0231403
  • DDB_0186120
  • DDB_0231403
  • GCS
  • GLCL
  • GLCLC
  • D9Wsu168e
  • GLCL-H
  • Ggcs-hs
  • Glclc
  • cb1049
  • fe36e11
  • wu:fe36e11
  • glutamate-cysteine ligase catalytic subunit
  • glutamate-cysteine ligase, catalytic subunit
  • Glutamate-cysteine ligase catalytic subunit
  • gamma glutamylcysteine synthetase
  • glutamate-cysteine ligase, catalytic subunit L homeolog
  • glutamate-cysteine ligase, catalytic subunit S homeolog
  • gamma-glutamylcysteine synthetase
  • GCLC
  • gclc
  • Gclc
  • LbGCS
  • gcsA
  • gclc.L
  • gclc.S
  • GSH1
Protein Region
Middle Region
Origin
Human
3
2
2
2
1
1
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
Options
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Blocked Antibody anti-Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) (Middle Region) antibody (ABIN2785780)
Sequence RISKSRYDSI DSYLSKCGEK YNDIDLTIDK EIYEQLLQEG IDHLLAQHVA
Characteristics This is a synthetic peptide designed for use in combination with anti-GCLC Antibody(ARP54577_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. GCLC is the catalytic subunit of 637 amino acids with a calculated molecular weight of 72.773 kDa. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.

Alias Symbols: GCL, GCS, GLCL, GLCLC

Protein Size: 637
Molecular Weight 73 kDa
Gene ID 2729
NCBI Accession NM_001498, NP_001489
UniProt P48506
Research Area Metabolism
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.