G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (C-Term) Peptide
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- Target See all GPBAR1 products
- GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AAAVPVAMGL GDQRYTAPWR AAAQRCLQGL WGRASRDSPG PSIAYHPSSQ
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GPBAR1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
- Synonyms
- BG37 Peptide, GPCR19 Peptide, GPR131 Peptide, M-BAR Peptide, TGR5 Peptide, Tgr5 Peptide, MGC84403 Peptide, GPBAR1 Peptide, Gpbar1 Peptide, GPCR Peptide, G protein-coupled bile acid receptor 1 Peptide, G protein-coupled bile acid receptor 1 S homeolog Peptide, GPBAR1 Peptide, Gpbar1 Peptide, gpbar1.S Peptide
- Background
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This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.
Alias Symbols: BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5
Protein Size: 330 - Molecular Weight
- 35 kDa
- Gene ID
- 151306
- NCBI Accession
- NM_170699, NP_733800
- UniProt
- Q8TDU6
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