Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (N-Term) Peptide
CXCR2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CXCR2 products
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-IL8RB antibody (Catalog #: ARP41956_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Chemokine (C-X-C Motif) Receptor 2 (CXCR2) peptide (Ovalbumin)
CXCR2 Reactivity: Human Host: Synthetic WB, Imm, SDS
Chemokine (C-X-C Motif) Receptor 2 (CXCR2) (AA 3-13) peptide (Ovalbumin)CXCR2 Reactivity: Mouse Host: Synthetic WB, Imm, SDS
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
- Synonyms
- CD182 Peptide, CDw128b Peptide, CMKAR2 Peptide, IL8R2 Peptide, IL8RA Peptide, IL8RB Peptide, CXC-R2 Peptide, CXCR-2 Peptide, CD128 Peptide, CDw128 Peptide, Cmkar2 Peptide, Gpcr16 Peptide, IL-8Rh Peptide, IL-8rb Peptide, Il8rb Peptide, mIL-8RH Peptide, C-X-C motif chemokine receptor 2 Peptide, chemokine (C-X-C motif) receptor 2 Peptide, Cxcr2 Peptide, CXCR2 Peptide
- Background
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IL8RB is the receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. IL8RB binds to IL-8 with high affinity. IL8RB also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CD182, CDw128b, CMKAR2, CXCR2, IL8R2, IL8RA, IL8RB
Protein Interaction Partner: ADRA1A,ARRB1,CXCL1,CXCL2,CXCL3,CXCL5,CXCL6,CXCR1,CXCR2,GNA14,GNA15,GNAI2,GNAI3,GPRASP1,GRIA1,IL8,MYO5B,PPBP,PPP2CA,RAB11FIP2,RGS12,ST13,ARRB1,CXCR2,GTF3A,IL8,MYO5B,RAB11FIP2,Rgs12
Protein Size: 360 - Molecular Weight
- 41 kDa
- Gene ID
- 3579
- NCBI Accession
- NM_001557, NP_001548
- UniProt
- P25025
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