Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (Middle Region) Peptide
KCNA1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all KCNA1 products
- KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-KCNA1 antibody (Catalog #: ARP34923_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))
- Synonyms
- AEMK Peptide, EA1 Peptide, HBK1 Peptide, HUK1 Peptide, KV1.1 Peptide, MBK1 Peptide, MK1 Peptide, RBK1 Peptide, KCNA1 Peptide, AI840627 Peptide, Kca1-1 Peptide, Kv1.1 Peptide, Mk-1 Peptide, Shak Peptide, mceph Peptide, Kcna Peptide, Kcpvd Peptide, potassium voltage-gated channel subfamily A member 1 Peptide, potassium voltage-gated channel, shaker-related subfamily, member 1 Peptide, fragile site, aphidicolin type, common, fra(12)(q24) Peptide, KCNA1 Peptide, Kcna1 Peptide, FRA12E Peptide
- Background
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KCNA1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene. This transcript is supported by sequences from mouse. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MGC126782, MGC138385, MK1, RBK1
Protein Interaction Partner: DLG1,DLG4,KCNE4,CNTNAP1,DLG4,KCNA2,KCNA3,KCNA4,RTN4
Protein Size: 495 - Molecular Weight
- 56 kDa
- Gene ID
- 3736
- NCBI Accession
- NM_000217, NP_000208
- UniProt
- Q09470
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