Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) Peptide
MANF
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all MANF products
- MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
- Protein Region
- C-Term
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EKICEKLKKK DSQICELKYD KQIDLSTVDL KKLRVKELKK ILDDWGETCK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MANF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) peptide
MANF Reactivity: Human, Dog, Mouse, Rat Host: Synthetic BP, Imm
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
- Synonyms
- ARMET Peptide, ARP Peptide, 3230402M22Rik Peptide, AA407711 Peptide, AA408789 Peptide, AA673178 Peptide, Armet Peptide, D17914 Peptide, D18Mgi17 Peptide, MANF Peptide, RBM15B Peptide, ARP-like Peptide, CG7013 Peptide, DmMANF Peptide, Dmel\\CG7013 Peptide, anon-EST:ParkEST188 Peptide, arp Peptide, armet Peptide, im:6909481 Peptide, zgc:153327 Peptide, manf Peptide, mesencephalic astrocyte derived neurotrophic factor Peptide, mesencephalic astrocyte-derived neurotrophic factor Peptide, RNA binding motif protein 15B Peptide, Mesencephalic astrocyte-derived neurotrophic factor Peptide, mesencephalic astrocyte-derived neurotrophic factor S homeolog Peptide, MANF Peptide, Manf Peptide, RBM15B Peptide, manf Peptide, manf.S Peptide
- Background
-
MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
Alias Symbols: ARMET, ARP, MGC142148, MGC142150
Protein Size: 185 - Molecular Weight
- 21 kDa
- Gene ID
- 7873
- NCBI Accession
- NM_006010, NP_006001
- UniProt
- A8K878
-
You are here:
