Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (N-Term) Peptide
MAP4K4
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all MAP4K4 products
- MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MAP4K4 antibody (Catalog #: ARP49031_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
- Synonyms
- FLH21957 Peptide, HGK Peptide, MEKKK4 Peptide, NIK Peptide, 9430080K19Rik Peptide, AU043147 Peptide, AU045934 Peptide, AW046177 Peptide, Nik Peptide, mitogen-activated protein kinase kinase kinase kinase 4 Peptide, MAP4K4 Peptide, Map4k4 Peptide
- Background
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MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: FLH21957, FLJ10410, FLJ20373, FLJ90111, HGK, KIAA0687, NIK, MEKKK4
Protein Interaction Partner: DOK1,GBP3,ITGB1,MAP3K7,NCK1,RAP2A,RASA1,SLC9A1,ATL1,BRCA1,GBP3,ITGB1,MAP3K1,MAP3K7,NCK1,RASA1,ZRANB1
Protein Size: 1166 - Molecular Weight
- 133 kDa
- Gene ID
- 9448
- NCBI Accession
- NM_004834, NP_004825
- UniProt
- O95819
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