NK6 Homeobox 1 (NKX6-1) (N-Term) Peptide
NKX6-1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NKX6-1 products
- NKX6-1 (NK6 Homeobox 1 (NKX6-1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NKX6-1 antibody (Catalog #: ARP32720_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NKX6-1 (NK6 Homeobox 1 (NKX6-1))
- Synonyms
- nkx6a Peptide, nkx6.1 Peptide, NKX6.1 Peptide, NKX6A Peptide, zgc:92879 Peptide, Nkx6.1 Peptide, Nkx61 Peptide, Nkx6a Peptide, NK6 homeobox 1 Peptide, NK6 homeobox 1 L homeolog Peptide, nkx6-1 Peptide, NKX6-1 Peptide, nkx6.1 Peptide, nkx6-1.L Peptide, Nkx6-1 Peptide
- Background
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NKX6-1 is the transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. NKX6-1 is involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3, NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. NKX6-1 belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-300 U66797.1 1-300 301-307 AC096766.3 119394-119400 c 308-676 U66797.1 308-676 677-849 U66798.1 7-179 850-1116 U66799.1 7-273
Alias Symbols: NKX6.1, NKX6A
Protein Size: 367 - Molecular Weight
- 38 kDa
- Gene ID
- 4825
- NCBI Accession
- NM_006168, NP_006159
- UniProt
- P78426
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