Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4) (N-Term) Peptide
PCSK4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PCSK4 products
- PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PCSK4 antibody (Catalog #: ARP58649_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))
- Synonyms
- PC4 Peptide, SPC5 Peptide, AI647044 Peptide, L21221 Peptide, NEC 3 Peptide, NEC3 Peptide, PCSK4 Peptide, pc4 Peptide, spc5 Peptide, MGC146505 Peptide, pcsk4 Peptide, proprotein convertase subtilisin/kexin type 4 Peptide, proprotein convertase subtilisin/kexin type 4 L homeolog Peptide, PCSK4 Peptide, Pcsk4 Peptide, pcsk4 Peptide, pcsk4.L Peptide
- Background
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PCSK4 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK4 plays a role in transcriptional coactivation. PCSK4 may be involved in stabilizing the multiprotein transcription complex.Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR, MIM 136950), and PACE4 (MIM 167405). Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-31 AC027307.5 80201-80231 c 32-257 AY358963.1 32-257 258-655 AK057235.1 452-849 656-2528 AY358963.1 656-2528 2529-2606 AL043305.1 210-287 2607-2674 AA453604.1 1-68 c
Alias Symbols: DKFZp434B217, MGC34749, PC4, SPC5
Protein Interaction Partner: IGF2
Protein Size: 755 - Molecular Weight
- 83 kDa
- Gene ID
- 54760
- NCBI Accession
- NM_017573, NP_060043
- UniProt
- Q6UW60
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