Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) (N-Term) Peptide
PSMC2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PSMC2 products
- PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PSMC2 antibody (Catalog #: ARP34239_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))
- Synonyms
- xMSS1 Peptide, psmc2 Peptide, DDBDRAFT_0168337 Peptide, DDBDRAFT_0232966 Peptide, DDB_0168337 Peptide, DDB_0232966 Peptide, MSS1 Peptide, Nbla10058 Peptide, S7 Peptide, NCU02840.1 Peptide, zgc:63995 Peptide, proteasome 26S subunit, ATPase 2 L homeolog Peptide, proteasome (prosome, macropain) 26S subunit, ATPase 2 Peptide, 26S protease regulatory subunit 7 Peptide, proteasome 26S subunit, ATPase 2 Peptide, regulatory particle, ATPase-like-1 Peptide, psmc2.L Peptide, psmc2 Peptide, psmC2 Peptide, PSMC2 Peptide, rpt-1 Peptide, GL50803_21331 Peptide, EHI_080890 Peptide, UREG_01412 Peptide, PITG_10169 Peptide, Psmc2 Peptide, GL50803_86683 Peptide, Tsp_09237 Peptide
- Background
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The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, PSMC2 is a positive modulator of Tat-mediated transactivation.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC3004, MSS1, Nbla10058, S7
Protein Interaction Partner: GRINL1A,GTF2B,GTF2F1,GTF2H1,NDC80,NDRG1,PSMC1,PSMC4,PSMD2,PSMD5,SKIL,SUMO4,TBP,TRAF6,ATXN7,GRINL1A,GTF2B,GTF2F1,GTF2H1,NDC80,PAAF1,PMS2,PSMC1,PSMC4,PSMD10,PSMD13,PSMD14,PSMD2,PSMD5,PSMD6,PSMD7,RPT1,TBP,TRAF6,UCHL5,USP14
Protein Size: 433 - Molecular Weight
- 49 kDa
- Gene ID
- 5701
- NCBI Accession
- NM_002803, NP_002794
- UniProt
- P35998
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