Glutaminyl-Peptide Cyclotransferase (QPCT) (Middle Region) Peptide
QPCT
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all QPCT products
- QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-QPCT antibody (Catalog #: ARP48743_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))
- Synonyms
- GCT Peptide, QC Peptide, sQC Peptide, QPCT Peptide, 5730422A13Rik Peptide, Qpctl1 Peptide, RGD1562284 Peptide, qpct Peptide, glutaminyl-peptide cyclotransferase Peptide, glutaminyl-peptide cyclotransferase (glutaminyl cyclase) Peptide, glutaminyl-peptide cyclotransferase L homeolog Peptide, QPCT Peptide, Qpct Peptide, M6_Spy0443 Peptide, M5005_Spy_0416 Peptide, M28_Spy0404 Peptide, CJA_2408 Peptide, CCNA_02733 Peptide, Tsp_03182 Peptide, qpct.L Peptide
- Background
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QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GCT, QC, sQC
Protein Size: 361 - Molecular Weight
- 38 kDa
- Gene ID
- 25797
- NCBI Accession
- NM_012413, NP_036545
- UniProt
- Q16769
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