Sin3A-Associated Protein, 18kDa (SAP18) Peptide
SAP18
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SAP18 products
- SAP18 (Sin3A-Associated Protein, 18kDa (SAP18))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SAP18 antibody (Catalog #: ARP38690_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SAP18 (Sin3A-Associated Protein, 18kDa (SAP18))
- Synonyms
- zgc:73118 Peptide, C530046K05Rik Peptide, D11Ertd539e Peptide, EMegR4 Peptide, Sinbp1 Peptide, 2HOR0202 Peptide, SAP18P Peptide, Sin3A-associated protein Peptide, Sin3-associated polypeptide 18 Peptide, Sin3A associated protein 18 Peptide, Sin3A associated protein 18kDa S homeolog Peptide, sap18 Peptide, Sap18 Peptide, sap18.S Peptide, SAP18 Peptide
- Background
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Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. SAP18 is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.
Alias Symbols: SAP18P, 2HOR0202
Protein Interaction Partner: HDAC1,IKZF1,NOL12,POLE2,RPS3A,SUFU,TADA3,ATP5L,C6orf211,DDOST,DDX3X,EIF3E,GLI1,GLI3,KIAA1279,NOL12,NSF,OSBPL10,POLE2,RGS10,RPN2,RPS3A,SIN3A,Shh,Sin3a,Sufu,TADA3,YARS
Protein Size: 153 - Molecular Weight
- 18 kDa
- Gene ID
- 10284
- NCBI Accession
- NM_005870, NP_005861
- UniProt
- O00422
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