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SH3 Domain Containing Ring Finger 1 (SH3RF1) (Middle Region) Peptide

SH3RF1 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN983699
  • Target See all SH3RF1 products
    SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))
    Protein Region
    Middle Region
    Origin
    Human
    Source
    • 1
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-SH3RF1 antibody (Catalog #: ARP43283_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))
    Synonyms
    SH3MD2 Peptide, posh Peptide, xPOSH Peptide, rnf142 Peptide, sh3md2 Peptide, MGC135632 Peptide, MGC189605 Peptide, POSH Peptide, RNF142 Peptide, 2200003J05Rik Peptide, Posh Peptide, R75531 Peptide, Sh3md2 Peptide, si:ch211-114c9.2 Peptide, si:dkey-15j16.4 Peptide, wu:fi42f11 Peptide, SH3 domain containing ring finger 1 Peptide, SH3 domain containing ring finger 1 S homeolog Peptide, SH3RF1 Peptide, sh3rf1 Peptide, sh3rf1.S Peptide, Sh3rf1 Peptide
    Background
    SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.

    Alias Symbols: FLJ21602, KIAA1494, POSH, RNF142, SH3MD2

    Protein Interaction Partner: ADAM15,AKT2,MAP3K10,MAP3K11,MAP3K12,MAP3K9,PAK2,RACGAP1,SEMA6A,SIAH1,AKT2,MAP3K11

    Protein Size: 888
    Molecular Weight
    93 kDa
    Gene ID
    57630
    NCBI Accession
    NM_020870, NP_065921
    UniProt
    Q7Z6J0
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