Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Middle Region) Peptide
SIGLEC10
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SIGLEC10 products
- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SIGLEC10 antibody (Catalog #: ARP50160_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
- Synonyms
- PRO940 Peptide, SIGLEC-10 Peptide, SLG2 Peptide, Siglecg Peptide, SIGLEC10 Peptide, slg2 Peptide, pro940 Peptide, siglec-10 Peptide, sialic acid binding Ig like lectin 10 Peptide, sialic acid binding Ig-like lectin 10 Peptide, sialic acid-binding Ig-like lectin 10 Peptide, SIGLEC10 Peptide, Siglec10 Peptide, LOC484343 Peptide, LOC100066644 Peptide, siglec10 Peptide, LOC100513863 Peptide, LOC100340374 Peptide
- Background
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SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764
Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2
Protein Interaction Partner: FLNA,PTPN6
Protein Size: 697 - Molecular Weight
- 76 kDa
- Gene ID
- 89790
- NCBI Accession
- NM_033130, NP_149121
- UniProt
- Q96LC7
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