Vacuolar-sorting Protein SNF8 (SNF8) (N-Term) Peptide
SNF8
Reactivity: Rat
Host: Synthetic
BP, WB
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- Target See all SNF8 products
- SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))
- Protein Region
- N-Term
- Origin
- Rat
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GTVLAEDQLA QMSKQLDMFK TNLEEFASKH KQEIRKNPEF RVQFQDMCAT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Snf8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))
- Synonyms
- d11moh34 Peptide, vps22 Peptide, Dot3 Peptide, EAP30 Peptide, VPS22 Peptide, D11moh34 Peptide, RGD1310144 Peptide, D11Moh34 Peptide, D11MOH34 Peptide, zgc:101578 Peptide, SNF8, ESCRT-II complex subunit Peptide, eap30 subunit of ell complex, putative Peptide, EAP30 subunit of ELL complex Peptide, SNF8, ESCRT-II complex subunit S homeolog Peptide, SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) Peptide, snf8 Peptide, TA17290 Peptide, TVAG_107410 Peptide, Bm1_05145 Peptide, SNF8 Peptide, Snf8 Peptide, snf8.S Peptide
- Background
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Snf8 is required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is a component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.
Alias Symbols: D11moh34, MGC105799, RGD1310144
Protein Size: 258 - Molecular Weight
- 28 kDa
- Gene ID
- 287645
- NCBI Accession
- NM_001007804, NP_001007805
- UniProt
- Q5RK19
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