TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) Peptide

Details for Product No. ABIN984763, Supplier: Log in to see
Protein Name
  • C86182
  • E430026L09Rik
  • I-TRAF
  • ITRAF
  • TRAF2
  • TRAF family member-associated NFKB activator
  • TRAF family member-associated Nf-kappa B activator
  • TANK
  • Tank
Protein Region
N-Term
Origin
Human
7
2
2
1
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Blocked Antibody anti-TANK antibody (TRAF Family Member-Associated NFKB Activator) (N-Term) (ABIN2780571)
Characteristics This is a synthetic peptide designed for use in combination with anti-TANK antibody (Catalog #: ARP38421_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, TANK can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation.The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: I-TRAF, TRAF2

Protein Interaction Partner: CHUK,CHUK,IKBKE,IKBKG,CHUK,IKBKB,IKBKE,IKBKG,MAP4K5,TBK1,TRAF1,TRAF2,TRAF3,USP7,ZC3H12A,CHUK,IKBKE,IKBKG,IRF3,IRF7,ITGB1BP1,TBK1,TRAF1,TRAF2,TRAF3,TRIM37,Tbk1,UBC,ZC3H12A

Protein Size: 425
Molecular Weight 48 kDa
Gene ID 10010
NCBI Accession NM_004180, NP_004171
UniProt Q92844
Research Area Immunology, Innate Immunity
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.