Transmembrane Protease, serine 6 (TMPRSS6) (N-Term) Peptide
TMPRSS6
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all TMPRSS6 products
- TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TMPRSS6 antibody (Catalog #: ARP53188_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
- Synonyms
- IRIDA Peptide, 1300008A22Rik Peptide, transmembrane protease, serine 6 Peptide, transmembrane serine protease 6 Peptide, Tmprss6 Peptide, TMPRSS6 Peptide
- Background
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TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Alias Symbols: IRIDA
Protein Interaction Partner: COL1A1,FN1,LAMA1
Protein Size: 811 - Molecular Weight
- 90 kDa
- Gene ID
- 164656
- NCBI Accession
- NM_153609, NP_705837
- UniProt
- Q8IU80
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