Tumor Protein P73 (TP73) (N-Term) Peptide
TP73
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Tumor Protein p73 (TP73) products
- Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TP73 antibody (Catalog #: ARP33457_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))
- Synonyms
- P73 Peptide, Trp73 Peptide, TP73 Peptide, tp73 Peptide, Tp73 Peptide, p73 Peptide, TAp73 Peptide, zp73theta Peptide, tumor protein p73 Peptide, transformation related protein 73 Peptide, TP73 Peptide, Tp73 Peptide, tp73 Peptide, Trp73 Peptide
- Background
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TP73 belongs to the p53 family. It participates in the apoptotic response to DNA damage. When overproduced, it activates transcription from p53-responsive promoters and induces apoptosis. TP53 may be a tumor suppressor protein. This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms, however, the biological validity and the full-length nature of most variants have not been determined.
Alias Symbols: P73
Protein Interaction Partner: HCVgp1,TP73,HCVgp1,CDKN1A,HCVgp1,HMGB1,PIN1,BAX,BIRC3,CDKN1A,DENND4A,EP300,GNB2L1,HCVgp1,HMGB1,ITCH,NEDD4,PFDN5,PIN1,TP53AIP1,TP73,TP73,YAP1,ABL1,BIN1,CABLES1,CDK1,CDK2,CEBPZ,CHD3,CREBBP,DAXX,EP300,GNB2L1,HECW2,HIPK2,HMGB1,HRAS,ITCH,KAT2B,MAPK8,MDM2,MDM4,MYC,NEDD4,NFYB,PFDN5,PIAS1,PML,PPP1R13B,SMAD2,SMAD3,TP53,TP63,TP73,WT1,WWOX,YAP1,ABL1,CEBPZ,CHD3,CHUK,GNB2L1,HIPK2,HIPK3,HMGB1,ITCH,MDM2,MYC,NFYB,NFYC,RB1,SUMO1,TDG,TP73,UBC,UBE2I,YAP1
Protein Size: 636 - Molecular Weight
- 69 kDa
- Gene ID
- 7161
- NCBI Accession
- NM_005427, NP_005418
- UniProt
- O15350
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