Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (N-Term) Peptide
TRPM8
Reactivity: Human
Host: Synthetic
BP, WB, IHC
-
- Target See all TRPM8 products
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- Protein Region
- N-Term
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TRPM8 antibody (Catalog #: ARP35357_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- Synonyms
- TRPM8 Peptide, trpp8 Peptide, ltrpc6 Peptide, trpm8b Peptide, LTRPC6 Peptide, TRPP8 Peptide, CMR1 Peptide, LTrpC-6 Peptide, Trp-p8 Peptide, transient receptor potential cation channel subfamily M member 8 Peptide, transient receptor potential cation channel subfamily M member 8b L homeolog Peptide, transient receptor potential cation channel, subfamily M, member 8 Peptide, TRPM8 Peptide, trpm8b.L Peptide, Trpm8 Peptide
- Background
-
TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Alias Symbols: LTRPC6, MGC2849, TRPP8
Protein Size: 1104 - Molecular Weight
- 128 kDa
- Gene ID
- 79054
- NCBI Accession
- NM_024080, NP_076985
- UniProt
- Q7Z2W7
-
You are here:
