Ubiquitin Specific Peptidase 20 (USP20) (Middle Region) Peptide
USP20
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all USP20 products
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-USP20 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Synonyms
- USP20 Peptide, vdu2 Peptide, lsfr3a Peptide, LSFR3A Peptide, VDU2 Peptide, hVDU2 Peptide, 1700055M05Rik Peptide, AI467231 Peptide, Vdu2 Peptide, im:7151955 Peptide, zgc:63661 Peptide, universal stress protein Peptide, ubiquitin specific peptidase 20 Peptide, ubiquitin specific peptidase 20 L homeolog Peptide, RR_RS15875 Peptide, USP20 Peptide, usp20 Peptide, Usp20 Peptide, usp20.L Peptide
- Background
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USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Alias Symbols: KIAA1003, LSFR3A, VDU2
Protein Interaction Partner: DIO2,PRKCI,ACADM,APBA2,ATAD3B,ATP6AP2,CALM1,DIO2,EIF3C,EIF3E,FECH,GPT2,HERC2,HERC2P2,HIF1A,LRRC59,MAP7D1,MYO1A,MYO1C,N4BP3,NEURL4,NUP153,PECI,PLEC,PLEKHA7,PLK1,POLDIP3,PSMD11,PSMD12,PSMD6,PSMD7,RAD17,RFC2,RFC3,RFC4,RGPD5,SUN2,SYTL4,UCHL3,USP21,VAPA,VAPB,V
Protein Size: 913 - Molecular Weight
- 102 kDa
- Gene ID
- 10868
- NCBI Accession
- NM_006676, NP_006667
- UniProt
- Q9Y2K6
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