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This study aimed to lay the groundwork to further study of Bhlhe40 function at myogenesis and adipogenesis in bovine and should significantly contribute to cattle breeding and genetics through MAS (show MAS1 Proteins) program
Expression of DEC1 is evolutionally conserved in zebrafish.
High BHLHE40 expression is associated with glioblastomas.
STRA13 may be essential for the progression of atopic dermatitis by interacting with hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-148b and hsamiR- 152.
BHLHE40 was identified as a viable candidate for which a droplet digital PCR assay for demethylation was developed. The assay revealed high demethylation in activated NK cells and low demethylation in naive NK, T- and B-cells. We conclude the NK cell methylome is plastic with potential for remodeling.
findings suggested that posttranslational modification of DEC1 in the form of SUMOylation may serve as a key factor that regulates the function of DEC1 in vivo
Study conclude that DeltaNp63 is a novel target of DEC1 and HDAC2 (show HDAC2 Proteins) and modulates the efficacy of HDAC (show HDAC3 Proteins) inhibitors in growth suppression and keratinocyte differentiation.
DEC1 expression is correlated with HIF-1alpha (show HIF1A Proteins) protein in gastric cancer cell line.
The hypoxia-regulated transcription factor DEC1 and its expression in gastric cancer are reported.
IL-1beta (show IL1B Proteins) can induce DEC1 and HIF-1alpha (show HIF1A Proteins) protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt (show AKT1 Proteins) phosphorylation.
DEC1 controls the response of p53 (show TP53 Proteins)-dependent cell survival vs. cell death to a stress signal through MIC-1 (show C18orf8 Proteins)
findings suggest that the repression of CYP3A4 (show CYP3A4 Proteins) by IL-6 (show IL6 Proteins) is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 (show CYP3A4 Proteins) to form CCCTGC-DEC1 complex
These results indicate that Bhlhe40 works as a cofactor of T-bet for enhancing IFN-gamma (show IFNG Proteins) production in iNKT cells.
Bhlhe40 expression identifies encephalitogenic Th cells and defines a PTX-IL-1 (show IL1A Proteins)-Bhlhe40 pathway active in experimental autoimmune encephalomyelitis.
Collectively, the data obtained in this study suggest that DEC1 is a novel negative regulator of hepatic FGF21 (show FGF21 Proteins) expression
establishes a crucial role of Bhlhe40 in mediating the repressive effect of hypoxia on myogenic differentiation and suggests that inhibition of Bhlhe40 or p53 (show TP53 Proteins) may facilitate muscle regeneration after ischemic injuries
There was an inverse relationship between DEC1 expression and AMPK (show PRKAA1 Proteins) activity. Our results suggest that DEC1 negatively regulates AMPK (show PRKAA1 Proteins) activity via LKB1 (show STK11 Proteins)
Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades.
Data indicate that bHLH transcription factors Bhlhe40 interacts with PGC-1alpha protein (PGC-1alpha) and represses its transcriptional activity.
abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 (show BHLHE41 Proteins) and SHARP2.
studies indicate that DEC1 is an important regulator of Srebp-1c (show SREBF1 Proteins) expression and links circadian rhythm to hepatic lipogenesis. Activation of Dec1 can alleviate the nonalcoholic fatty liver phenotype
Study demonstrates that DEC1 is involved in osteogenesis.
This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differentiation.
basic helix-loop-helix family, member e40
, class E basic helix-loop-helix protein 40-like
, basic helix-loop-helix domain containing, class B, 2
, bHLH protein DEC1
, class E basic helix-loop-helix protein 40
, transmembrane protein 2
, FANCM-interacting histone fold protein 2
, Fanconi anemia-associated polypeptide of 10 kDa
, centromere protein X
, stimulated by retinoic acid 13 homolog
, stimulated by retinoic acid gene 13 protein homolog
, class B basic helix-loop-helix protein 2
, differentially expressed in chondrocytes 1
, differentially expressed in chondrocytes protein 1
, differentiated embryo chondrocyte expressed gene 1
, enhancer-of-split and hairy-related protein 2
, stimulated by retinoic acid gene 13 protein
, E47 interaction protein 1
, basic helix-loop-helix domain containing, class B2
, cytokine response gene 8
, eip1 (E47 interaction protein 1)
, enhancer-of split and hairy-related protein 2
, stimulated by retinoic acid 14
, Class B basic helix-loop-helix protein 2
, basic helix-loop-helix domain containing class B2 protein