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Findings show that mutation in OPN1MW underlie the cone dysfunction in all of the subjects tested, the color vision defect can be caused either by the same mutation or a gene rearrangement at the same locus.
Data suggest that OPN1MW exhibits a conserved Pro-Pro motif in extracellular loop 2 as observed in monostable visual G-protein-coupled receptors; comparison of deuterium uptake between inactive and active states of OPN1MW suggests a reduced solvent accessibility of the extracellular N-terminal region and an increased accessibility of the chromophore binding site.
Data suggest that insights into dimerization interface of red cone opsin should aid investigations of the structure and function of GPCR cell signaling.
Identification of one single red-green OPN1LW/MW hybrid gene harboring a point mutation that associates with blue cone monochromatism.
The photoreceptor phenotype associated with OPN1LW and OPN1MW mutations is highly variable. These findings have implications for the potential restoration of visual function in subjects with opsin (show RHO Antibodies) mutations.
Missense mutatin in both OPN1LW and OPN1MW cause X-linked cone dystrophy.
Mutations in the LW/MW cone opsin (show RHO Antibodies) gene array can, therefore, lead to a spectrum of disease, ranging from color blindness to progressive cone dystrophy (XLCOD5).
In Japanese males with congenital red/green color blindness the mutation Asn94Lys (AAC-->AAA) occurred in the single green gene of a deutan subject (A155); and Arg330Gln (CGA-->CAA) in both green genes of another, affecting protein folding and function
Abnormal distribution of cone green opsin is associated with autosomal dominant cone dystrophy
11-cis (show CISH Antibodies)-retinol inactivates expressed cone opsins, acting an inverse agonist
quantitative FRET analysis in acutely isolated cone OS revealed that the cone degeneration-causing V268I mutation in peripherin-2 (show PRPH2 Antibodies) selectively reduced binding to M-opsin without affecting the peripherin-2 (show PRPH2 Antibodies) interaction to S-opsin (show OPN1SW Antibodies) or rhodopsin (show RHO Antibodies)
Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2 (show THRB Antibodies), and rather enhanced by COUP-TFII (show NR2F2 Antibodies).
ectopically expressed cTalpha (show PCYT1A Antibodies) 1) forms a heterotrimeric complex with rod Gbeta (show SUCLG2 Antibodies)(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin (show RHO Antibodies) or S-cone opsin (show RHO Antibodies)
results show that UV-opsin (show RHO Antibodies) suppression successively ceases in presence of the M-opsin activating background light, which implies that cone light adaptation is controlled at the opsin (show RHO Antibodies) stage, before activation of transducin (show GNAT1 Antibodies).
Thus, the three types of mouse opsin (show RHO Antibodies) appear distinctive in the degree to which their bleached, unregenerated opsins generate "dark light."
alpha transducin (show GNAT1 Antibodies) and opsin (show RHO Antibodies) have roles in mouse photoreceptor cell responses to light and dark
The apparent decline in opsin (show RHO Antibodies) 1 opponency from superior to inferior retina is consistent with the dual gradient and a model where photoreceptor signals in both superior and inferior retina
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness.
green cone photoreceptor pigment
, green-sensitive opsin
, medium-wave-sensitive opsin 1
, MWS opsin
, green LWS photopigment
, green long wavelength sensitive cone opsin
, medium wavelength-sensitive cone opsin
, midwavelength sensitive opsin
, green sensitive cone opsin
, opsin CHK-1
, green-sensitive opsin-2
, opsin RH2-2
, opsin-1, medium-wave-sensitive 2
, green cone photoreceptor pigment 2
, green-sensitive opsin-3
, opsin RH2-3
, opsin-1, medium-wave-sensitive 3
, green cone photoreceptor pigment 3
, cone dystrophy 5 (X-linked)
, green cone pigment
, photopigment apoprotein
, opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan), green opsin
, opsin 1, long-wave-sensitive
, green opsin
, opsin 1 (cone pigments), medium-wave-sensitive
, green-sensitive opsin-like