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|Antigen||Cyclin A2 (CCNA2) Antibodies|
|Conjugate||This Cyclin A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-Cyclin A AntibodyTarget Details Cyclin A Application Details Handling References for anti-Cyclin A antibody (ABIN359544) Images
|Specificity||This antibody reacts to Cyclin A (CCNA2).|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the N-term of human CCNA2.|
Target Details Cyclin AProduct Details anti-Cyclin A Antibody Application Details Handling References for anti-Cyclin A antibody (ABIN359544) Images back to top
|Alternative Name||Cyclin A2 (CCNA2 Antibody Abstract)|
|Background||CCNA2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.Synonyms: CCN1, CCNA, CCNA2, Cyclin A, Cyclin-A2|
|Gene ID||890, 9606|
|Research Area||Cell Cycle|
|Pathways||PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA|
Application DetailsProduct Details anti-Cyclin A Antibody Target Details Cyclin A Handling References for anti-Cyclin A antibody (ABIN359544) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Cyclin A Antibody Target Details Cyclin A Application Details References for anti-Cyclin A antibody (ABIN359544) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-Cyclin A antibody (ABIN359544)Product Details anti-Cyclin A Antibody Target Details Cyclin A Application Details Handling Images back to top
Tsang, Wang, Chen, Sánchez, Dynlacht: "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression." in: The Journal of cell biology, Vol. 178, Issue 4, pp. 621-33, 2007
Henglein, Chenivesse, Wang, Eick, Bréchot: "Structure and cell cycle-regulated transcription of the human cyclin A gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5490-4, 1994
Wang, Chenivesse, Henglein, Bréchot: "Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma." in: Nature, Vol. 343, Issue 6258, pp. 555-7, 1990
ImagesProduct Details anti-Cyclin A Antibody Target Details Cyclin A Application Details Handling References for anti-Cyclin A antibody (ABIN359544) back to top