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|Application / Reactivity||Human|
|Dot Blot (DB)||1 Antibodies|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Immunofluorescence (IF)||33 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||47 Antibodies|
|Immunohistochemistry (IHC)||42 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||26 Antibodies|
|Immunoprecipitation (IP)||2 Antibodies|
|Western Blotting (WB)||137 Antibodies|
|Antigen||Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) Antibodies|
|Epitope||C-Term, AA 850-906 Alternatives|
|Conjugate||This GRIA1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-GRIA1 AntibodyTarget Details GRIA1 Application Details Handling References for anti-GRIA1 Antibody (ABIN493014) Images
|Specificity||This antibody detects a single band of approximately 109 kDa og GluR1.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human|
|Immunogen||Synthetic peptide corresponding to C-terminal of GluR1 (aa 850-906)|
Target Details GRIA1Product Details anti-GRIA1 Antibody Application Details Handling References for anti-GRIA1 Antibody (ABIN493014) Images back to top
|Alternative Name||Glutamate Receptor 1 / GLUR1 (GRIA1 Antibody Abstract)|
|Background||Glutamate receptor 1 (GluR-1) is a predominant excitatory neurotransmitter receptor in the mammalian brain. It belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors (1). Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. These receptors are classified on the basis of their activation by different pharmacologic agonists (2). GluR-1 is known to bind a kainate subtype of agonist. The gene encoding GluR1 is located at human chromosome 5q33 (3). GluR1 is of medical interest because it plays an important role in many biological functions. GluR1 controls dendrite growth and is both necessary and sufficient to control motor neuron dendrite geometry (4). It is postulated to be implicated in susceptibility to schizophrenia (5). It may play an important role in tumor invasion, in the mediation of excitation-induced neuronal cell death in stroke and inherited neurodegenerative-disorders and in the pathophysiology and treatment of manic-like behaviors (6). GluR1 is widely expressed in brain. In the spinal cord, GluR1is expressed in motor neurons exclusively during the early postnatal life when their dendrites undergo large-scale growth (4). GluR1 is approximately a 109 kDa protein (906 amino acids).Synonyms: AMPA-selective glutamate receptor 1, AMPA1, GLUH1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic|
Application DetailsProduct Details anti-GRIA1 Antibody Target Details GRIA1 Handling References for anti-GRIA1 Antibody (ABIN493014) Images back to top
ELISA: < 1: 10,000. Western blot: > 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-GRIA1 Antibody Target Details GRIA1 Application Details References for anti-GRIA1 Antibody (ABIN493014) Images back to top
|Concentration||0.64 - 0.72 mg/mL (lot specifc)|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Store (in aliquots) at -20 °C.|
References for anti-GRIA1 Antibody (ABIN493014)Product Details anti-GRIA1 Antibody Target Details GRIA1 Application Details Handling Images back to top
Lee, Takamiya, He et al.: "Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus." in: Journal of neurophysiology, Vol. 103, Issue 1, pp. 479-89, 2010 (PubMed).
Zhou, Zhang, Guoxiang et al.: "GluR1 controls dendrite growth through its binding partner, SAP97." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 41, pp. 10220-33, 2008 (PubMed).
Pei, Ritz, McCarthy et al.: "Receptor occupancy and channel-opening kinetics: a study of GLUR1 L497Y AMPA receptor." in: The Journal of biological chemistry, Vol. 282, Issue 31, pp. 22731-6, 2007 (PubMed).
Magri, Gardella, Barlati et al.: "Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 141B, Issue 3, pp. 287-93, 2006 (PubMed).
Gregor, Reeves, Jabs et al.: "Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 7, pp. 3053-7, 1993 (PubMed).
Puckett, Gomez, Korenberg et al.: "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 17, pp. 7557-61, 1991 (PubMed).