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anti-Human GRIA1 antibody for Enzyme Immunoassay

Recommended GRIA1 Antibody (supplied by: Log in to see )

Antigen
Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) Antibodies
  • 2900051M01Rik
  • Glr-1
  • Glr1
  • GluA1
  • GLUH1
  • Glur-1
  • gluR-A
  • GluR-A
  • gluR-K1
  • glur1
  • Glur1
  • GLUR1
  • GLURA
  • GluRA
  • GRIA1
  • HBGR1
  • HIPA1
Epitope
C-Term, AA 850-906
43
36
28
24
22
21
15
13
13
12
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
197
193
159
8
7
6
3
2
2
Host
Rabbit
209
48
5
Clonality
Polyclonal
Conjugate
This GRIA1 antibody is un-conjugated
7
6
5
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
196
78
51
45
40
40
24
9
5
2
2
1
1
1
Supplier
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Catalog No. ABIN493014
$ 456.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008913908 ABIN783978 EIA WB Goat Internal Region, AA 264-277 Log in to see Polyclonal
0.0008913908 ABIN1107383 EIA IHC (fro) WB Rabbit C-Term Log in to see Polyclonal

Top referenced anti-GRIA1 antibody for Enzyme Immunoassay

  • Human Polyclonal GRIA1 Primary Antibody for EIA, WB - ABIN493014 (6 Publications): Gregor, Reeves, Jabs, Yang, Dackowski, Rochelle, Brown, Haines, OHara, Uhl: Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)

Similar anti-GRIA1 Antibodies

Application / Reactivity Human
Dot Blot (DB) 1 Antibodies
ELISA 35 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 5 Antibodies
Immunofluorescence (IF) 33 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 45 Antibodies
Immunohistochemistry (IHC) 42 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 26 Antibodies
Immunoprecipitation (IP) 2 Antibodies
Western Blotting (WB) 137 Antibodies

General

Antigen Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) Antibodies
Epitope C-Term, AA 850-906
(43), (36), (28), (24), (22), (21), (15), (13), (13), (12), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(197), (193), (159), (8), (7), (6), (3), (2), (2)
Host Rabbit
(209), (48), (5)
Clonality
Polyclonal
Conjugate This GRIA1 antibody is un-conjugated
(7), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(196), (78), (51), (45), (40), (40), (24), (9), (5), (2), (2), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-GRIA1 Antibody

Target Details GRIA1 Application Details Handling References for anti-GRIA1 Antibody (ABIN493014) Images
Specificity This antibody detects a single band of approximately 109 kDa og GluR1.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity chromatography
Immunogen Synthetic peptide corresponding to C-terminal of GluR1 (aa 850-906)

Target Details GRIA1

Product Details anti-GRIA1 Antibody Application Details Handling References for anti-GRIA1 Antibody (ABIN493014) Images back to top
Antigen
Alternative Name Glutamate Receptor 1 / GLUR1 (GRIA1 Antibody Abstract)
Background Glutamate receptor 1 (GluR-1) is a predominant excitatory neurotransmitter receptor in the mammalian brain. It belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors (1). Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. These receptors are classified on the basis of their activation by different pharmacologic agonists (2). GluR-1 is known to bind a kainate subtype of agonist. The gene encoding GluR1 is located at human chromosome 5q33 (3). GluR1 is of medical interest because it plays an important role in many biological functions. GluR1 controls dendrite growth and is both necessary and sufficient to control motor neuron dendrite geometry (4). It is postulated to be implicated in susceptibility to schizophrenia (5). It may play an important role in tumor invasion, in the mediation of excitation-induced neuronal cell death in stroke and inherited neurodegenerative-disorders and in the pathophysiology and treatment of manic-like behaviors (6). GluR1 is widely expressed in brain. In the spinal cord, GluR1is expressed in motor neurons exclusively during the early postnatal life when their dendrites undergo large-scale growth (4). GluR1 is approximately a 109 kDa protein (906 amino acids).Synonyms: AMPA-selective glutamate receptor 1, AMPA1, GLUH1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic
Gene ID 2890
NCBI Accession NP_000818
UniProt P42261
Pathways PI3K-Akt Signaling

Application Details

Product Details anti-GRIA1 Antibody Target Details GRIA1 Handling References for anti-GRIA1 Antibody (ABIN493014) Images back to top
Application Notes ELISA: < 1: 10,000. Western blot: > 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-GRIA1 Antibody Target Details GRIA1 Application Details References for anti-GRIA1 Antibody (ABIN493014) Images back to top
Concentration 0.64 - 0.72 mg/mL (lot specifc)
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.

References for anti-GRIA1 Antibody (ABIN493014)

Product Details anti-GRIA1 Antibody Target Details GRIA1 Application Details Handling Images back to top
Background publications

Lee, Takamiya, He, Song, Huganir: "Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus." in: Journal of neurophysiology, Vol. 103, Issue 1, pp. 479-89, 2010

Zhou, Zhang, Guoxiang, Mojsilovic-Petrovic, Takamaya, Sattler, Huganir, Kalb: "GluR1 controls dendrite growth through its binding partner, SAP97." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 41, pp. 10220-33, 2008

Pei, Ritz, McCarthy, Huang, Niu: "Receptor occupancy and channel-opening kinetics: a study of GLUR1 L497Y AMPA receptor." in: The Journal of biological chemistry, Vol. 282, Issue 31, pp. 22731-6, 2007

Magri, Gardella, Barlati, Podavini, Iatropoulos, Bonomi, Valsecchi, Sacchetti, Barlati: "Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 141B, Issue 3, pp. 287-93, 2006

Gregor, Reeves, Jabs, Yang, Dackowski, Rochelle, Brown, Haines, OHara, Uhl: "Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 7, pp. 3053-7, 1993

Puckett, Gomez, Korenberg, Tung, Meier, Chen, Hood: "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 17, pp. 7557-61, 1991