Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) Antibodies
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
This MAPKAP1 antibody is un-conjugated
Western Blotting (WB)
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Protein A purified antibody
A recombinant protein fragment from the C-terminal region of human SIN1 was used as the immunogen for this antibody.
MAPKAP1 Antibody Abstract)
MTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.
PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events
Provided assay concentrations are suggestions only, SIN1 antibody titration may be required for optimal results.\. Western blot: 1-3 μg/mL
For Research Use only
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Aliquot and store frozen at -20°C or colder to avoid repeated freeze-thaw cycles.
Western blot testing of human samples with SIN1 antibody at 1ug/ml.