Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, Turkey, Sheep, Bovine, Dog, Horse, Guinea pig, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, West Indian ocean coelacanth, Duckbill platypus, Tasmanian devil,Zebra finch.
The immunogen recognized by this antibody maps to a region between residue 470 and the C-terminus (residue 522) of human stress-activated map kinase interacting protein 1 using the numbering given in entry NP_001006618.1 (GeneID 79109).
Sin1 is a novel component of the eukaryotic SAPK pathway. Sin1 and the H3 and H4histones interact genetically, with the C terminus of Sin1 physically associating withcomponents of the SWI-SNF complex. This interaction is blocked by the N-terminal halfof the protein in full length Sin1. It has been proposed that Sin1 acts as a regulatablebridge between the SWI-SNF complex and the nucleosome Sin1 is also required foreffective transcription via the AP-1 factor Pap1, but does not prevent its nucleartranslocation. Sin1 is a novel component of the eukaryotic SAPK pathway. Alternate Names: anti-Sin1 antibody, anti-SIN-1 antibody, anti-Stress Activated Map Kinase(SAPK)-Interacting Protein 1 antibody, anti-MAPKAP1 antibody, anti-Mitogen-ActivatedProtein Kinase Associated Protein 1 antibody, anti-MIP antibody,anti-MEKK2-Interacting Ptoein 1 antibody, anti-MGC2745 antibody, anti-Ras InhibitorMGC27. Gene Symbol: MAPKAP1
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