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Cow (Bovine) Polyclonal ZFAND5 Primary Antibody for WB - ABIN2775778
Hishiya, Ikeda, Watanabe: A RANKL-inducible gene Znf216 in osteoclast differentiation. in Journal of receptor and signal transduction research 2005
Show all 2 Pubmed References
Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin (show ZFP36 Antibodies) for mRNA binding.
redundant and distinct roles in regulating NFkappaB activation and apoptosis
ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B (show NFKB1 Antibodies) pathway
ZNF216 functions in protein degradation via the UPS and plays a crucial role in muscle atrophy.
Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
AN1-type zinc finger protein 5
, zinc finger A20 domain-containing protein 2
, zinc finger protein 216
, zinc finger, A20 domain containing 2
, EST00848 homolog