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Healthy human eosinophils express functional P2X1 receptors whose activation leads to eosinophil alphaMbeta2 integrin-dependent adhesion. P2X1 responses are constitutively reduced in asthmatic compared with healthy eosinophils, probably as the result of an increase in extracellular nucleotide concentration.
the expression of P2X1 transcript and its splicing variant P2X1del in most human monocytes
These data suggest that vascular smooth muscle cells from human gastro-omental arteries express P2X1 and P2X4 (show P2RX4 ELISA Kits) receptor subunits
enhances platelet activation evoked by mild stimulants via the p38 (show CRK ELISA Kits) signalling pathway
In conclusion, our results demonstrate for the first time that adenine nucleotides acting at P2X1 receptors inhibit the proliferation of human coronary smooth muscle cells via the induction of the early gene NR4A1 (show NR4A1 ELISA Kits).
With the development of leukemia, the expression of P2X7R (show P2RX7 ELISA Kits) increased in both bone marrow and spleen macrophages whereas expression of P2X1 Receptor increased in spleen macrophages.
Increased P2X1 receptor expression and ATP release may have contributed to the augmentation of contractile response induced by hypoxia-glucopenia and reoxygenation in he detrusor muscles.
Data indicate that MgATP2- activates P2X1 and P2X3 (show P2RX3 ELISA Kits), but not P2X2 (show P2RX2 ELISA Kits) and P2X4 (show P2RX4 ELISA Kits) receptors.
These results suggest that conformational change in the P2X1 receptor is required for co-ordination of ATP action.
HSP90 (show HSP90 ELISA Kits) inhibitors may be as effective as selective antagonists in regulating platelet P2X1 receptors, and their potential effects on hemostasis should be considered in clinical studies.
Quite the reverse is seen in P2X1(-/-) mice, which had markedly lower cytokine levels and less coagulation activation compared to controls after exposure to uropathogenic Escherichia coli.
secretion of IL-22 (show IL22 ELISA Kits) in the regenerating liver is modulated by the ATP receptor (show P2RX4 ELISA Kits), P2X1
Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor (show TBXA2R ELISA Kits), which partially requires the activation of P2X1R through an endothelium-dependent mechanism.
This study reveals a major role for the P2X1 receptor in LPS (show TLR4 ELISA Kits)-induced lethal endotoxemia through its critical involvement in neutrophil emigration from venules.
NTPDase1 (show ENTPD1 ELISA Kits) controls male fertility via the regulation of P2X1 activation.
The presence of the P2X1 receptor on both polymorphonuclear neutrophils and platelets is important for fibrin generation and thrombus formation in vivo.
Male contraception via simultaneous knockout of alpha1A (show CACNA1A ELISA Kits)-adrenoceptors and P2X1-purinoceptors in mice.
loss of Dicer (show DICER1 ELISA Kits) may impair the expression of miRNAs that are capable of targeting P2x mRNAs.
The activity of P2X2 (show P2RX2 ELISA Kits)/3 receptors in nodose ganglion neurons is involved in the transmission of myocardial ischemic nociceptive signal.
The P2X receptor phenotype in megakaryocytes and (by inference) platelets is due to expression of homomeric P2X1 receptors.
The authors show that porcine circovirus type 2 infection upregulated calcium/calmodulin-dependent protein kinase kinase-beta (show CAMKK2 ELISA Kits) (CaMKKbeta) by increasing cytosolic Ca(2 (show CA2 ELISA Kits)+) via inositol 1,4,5-trisphosphate receptor (IP3R (show ITPR1 ELISA Kits)).
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
P2X purinoceptor 1
, ATP receptor
, P2X receptor, subunit 1
, P2X1 receptor
, purinergic receptor P2X1
, programmed cell death 3
, RP-2 protein