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Dapper1 attenuates hepatic gluconeogenesis and lipogenesis in Ttype 2 diabetes.
Dpr1 promotes the ubiquitination of Dvl2 (show DVL2 Proteins) by pVHL (show VHL Proteins) and mediates the protein aggregate-elicited autophagy initiation
Expression analysis of Dact1-LacZ (show GLB1 Proteins) show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues.
These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 (show DVL1 Proteins) and possibly Disrupted in Schizophrenia-1 (show DISC1 Proteins), in the formation of synapses on cortical interneuron dendrites.
Depletion of Dapper-1 and dishevelled-2 (show DVL2 Proteins) in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 (show DVL2 Proteins) and that activity of both Dapper-1 and dishevelled-2 (show DVL2 Proteins) is essential for activating canonical Wnt (show WNT2 Proteins) signaling.
conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl (show DVL1 Proteins).
Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages.
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled (show DVL2 Proteins) activity and leads to posterior malformation in mice.
This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac (show AKT1 Proteins)
Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis
frd1 is expressed in the developing brain and mesoderm.
two Dvl (show DVL2 Proteins)-associated paralogs, Dpr1 and Dpr2 (show DACT2 Proteins), participate in distinct Wnt (show WNT2 Proteins)-dependent developmental processes
target of beta-catenin (show CTNNB1 Proteins) and/or an unknown downstream effector in development
An inhibitory role for DACT1 in leukemogenesis.
Dact1 is up-regulated by TGF-beta1 (show TGFB1 Proteins), inducing apoptosis in mesangial cells.
The simultaneous methylation of DACT1 and DACT2 (show DACT2 Proteins) may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt (show WNT2 Proteins)/beta catenin (show CTNNB1 Proteins) signaling.
our results suggested that DACT1 was upregulated during human placenta development.
There was no statistical difference between groups concerning DACT1 and DACT2 (show DACT2 Proteins) either in promoter hypermethylation or transcript levels. Age was associated with DACT2 (show DACT2 Proteins) promoter hypermethylation, especially over 56 years old.
Overexpression of Dapper-1 allows the translocation of MIZ-1 (show ZBTB17 Proteins) from the nucleus to the cytoplasm.
Dpr1 directly interacts with Beclin1 (show BECN1 Proteins) and Atg14L and enhances the Beclin1 (show BECN1 Proteins)-Vps34 (show PIK3C3 Proteins) interaction and Vps34 (show PIK3C3 Proteins) activity.
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.
dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
, dapper 1
, dapper, antagonist of beta-catenin
, dapper, antagonist of beta-catenin, homolog 1
, dapper homolog 1-like
, dapper antagonist of catenin 1
, dapper homolog 1
, frodo homolog
, thymus expressed gene 3
, thymus-expressed novel gene 3 protein
, dishevelled-interacting protein
, frodo 1
, hepatocellular carcinoma novel gene 3 protein
, heptacellular carcinoma novel gene 3
, dapper 1-B
, dapper homolog 1, antagonist of beta-catenin