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Beta-arrestin-1 with beta-arrestin-2 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.
data suggest that beta-arr1 mediated nuclear signaling regulates the production of excretive factors derived from niche astrocytes and expansion of neural precursors in DG, thus maintaining homeostasis of adult hippocampal neurogenesis
beta-arr1 (show SAG ELISA Kits) has a critical role in modulating ERK (show EPHB2 ELISA Kits), JNK (show MAPK8 ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) pathways mediated by TNF-alpha (show TNF ELISA Kits) in intestinal epithelial cells.
COX-2-derived PGE2 inhibits IL-10 expression in brain microglia through a novel EP2- and beta-arrestin-dependent signaling pathway.
A specific hyaluronan-blocking peptide (Pep-1 (show CNDP2 ELISA Kits)) has confirmed the inflammatory role of degraded hyaluronan as a mediator of the IL-1beta (show IL1B ELISA Kits)-induced activation of beta-arrestin-1.
Data suggest that ARRB1 enhances hepatocellular carcinogenesis by inflammation-mediated Akt (show AKT1 ELISA Kits) signaling.
Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.
Data show that knockout or knockdown of beta-arrestin-2 (show ARRB2 ELISA Kits) (betaarr-2), but not of beta-arrestin-1 (betaarr-1), augments beta adrenoceptor (betaAR)-stimulated cyclic AMP (show TMPRSS5 ELISA Kits) (cAMP) production.
a neuroprotective role for ARRB1, in the context of cerebral ischemia, centered on the regulation of BECN1 (show BECN1 ELISA Kits)-dependent autophagosome formation
results indicate that beta-arrestin1 plays a critical role in the assembly and activation of two major canonical inflammasomes
In non-small cell lung cancer patients, the loss expression of beta-arrestin1 was frequently observed, and beta-arrestin1 expression was significantly correlated with the smoking index and E-cadherin (show CDH1 ELISA Kits) expression, which all indicated beta-arrestin1's significant clinicopathologic role
beta-arrestins regulate oxidative stress in a Nox4 (show NOX4 ELISA Kits)-dependent manner and increase fibrosis in heart failure.
These results indicated that b-arr1 regulated ER stress/PUMA-induced mucosal epithelial apoptosis through suppression of the TNF-a/p65/iNOS signaling pathway activation and that b-arr1 is a potential therapeutic target for Portal hypertensive gastropathy.
The nuclear accumulation of beta-arrestin 1 following TLR2 (show TLR2 ELISA Kits) activation promote H4 acetylation at specific target gene promoters and may thus affect transcription of target genes in BM CD34 (show CD34 ELISA Kits)+ cells.
The identified receptor-phospho-selective mechanism for arrestin (show SAG ELISA Kits) conformation and the spacing of the multiple phosphate-binding sites in the arrestin (show SAG ELISA Kits) enable arrestin (show SAG ELISA Kits) to recognize plethora phosphorylation states of numerous GPCRs.
We conclude that beta-arrestin1 had a high expression in lung adenocarcinoma and beta-arrestin1 may be a promising biomarker to identify individuals with poor prognosis for patients with lung adenocarcinoma.
Bradykinin stimulates pro-contractile signalling mechanisms in human myometrial cells and arrestin (show SAG ELISA Kits) proteins play key roles in their regulation.
After eight and 12 weeks of treatment with mirtazapine, scores on the 21-item Hamilton Depression Rating Scale (HAMD21) were significantly lower in patients with MDD with ARRB1 haplotype 1 than in those without haplotype 1
analysis of how NK1 receptor Gs versus Gq proteins and beta-arrestin signaling is determined by interactions in the water hydrogen bond network
Using in vivo time-lapse imaging and three-dimensional morphology analysis of microglia in intact zebrafish larvae, study found that beta-arrestin1, a multifunctional protein involved in various signal transductions, cell-autonomously regulated the microglial morphology.
Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1 (show YY1 ELISA Kits), thus relieving PcG-mediated repression of cdx4-hox (show MSH2 ELISA Kits) pathway.
The presented functional map quantitatively connects critical interactions in the polar core and along the C tail of arrestin (show SAG ELISA Kits).
Reduced binding of arrestin-1 (show SAG ELISA Kits) to the phospho-opsin (show RHO ELISA Kits) form of G90D mutant likely contributes to night blindness caused by this mutation.
3.0 A crystal structure of the bovine arrestin-1 splice variant p44, in which the activation step is mimicked by C-tail truncation
Conformational dynamics of helix 8 in the GPCR (show GPRC6A ELISA Kits) rhodopsin (show RHO ELISA Kits) controls arrestin (show SAG ELISA Kits) activation in the desensitization process
similar to transducin (show GNAT1 ELISA Kits) activation, rhodopsin (show RHO ELISA Kits) phosphorylation by GRK1 (show GRK1 ELISA Kits) and high affinity arrestin-1 (show SAG ELISA Kits) binding only requires a rhodopsin (show RHO ELISA Kits) monomer
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
arrestin, beta 1
, arrestin 1
, beta-arrestin 1
, arrestin beta 1
, arrestin beta-1
, arrestin 2