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Low MZB1 expression was an independent prognostic factor for recurrence after curative gastrectomy and was associated significantly with increased hematogenous recurrence. MZB1 acts as a suppressor of GC. Low MZB1 expression in the primary GC tissue is predictive of recurrence after curative resection.
High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.
miR (show MLXIP Proteins)-185 regulates T cell development through its targeting of several mRNAs including Mzb1.
methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis
Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer.
MZB1 seems to act as a substrate-specific cochaperone of GRP94 (show HSP90B1 Proteins) that enables proper biosynthesis of microHCs under conditions of ER stress.
Mzb1 helps to diversify peripheral B cell functions by regulating Ca(2 (show CA2 Proteins)+) stores, antibody secretion, and integrin activation.
Data suggest that pERp1 is either a unique type of oxidoreductase (show HSD17B6 Proteins) or a previously unidentified class of molecular chaperone (show HSP90AA1 Proteins) that is dedicated to enhancing the oxidative folding of Ig precursors.
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity).
Proapoptotic caspase adapter protein
, marginal zone B- and B1-cell-specific protein
, plasma cell-induced ER protein 1
, plasma cell-induced resident ER protein
, plasma cell-induced resident endoplasmic reticulum protein
, caspase-2 binding protein
, mesenteric estrogen-dependent adipose 7
, mesenteric oestrogen-dependent adipose gene- 7
, proapoptotic caspase adapter protein
, proapoptotic caspase adaptor protein