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AtRAN1 plays an important role in vegetative growth and the molecular improvement of stress tolerance in Arabidopsis. AtRAN1 overexpression promoted vegetative growth and enhanced abiotic tolerance, while the atran1 atran3 double mutant showed higher freezing sensitivity than WT.
RAN1 is essential for biogenesis of the ETR1 and copper homeostasis.
A novel role was identified for two microtubule-growth and nucleation agents, Ran and CLASP (show CLASRP Proteins), in the establishment of the centrosome-independent force during anaphase during Caenorhabditis elegans mitosis.
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).