CHMP2A Protein (AA 1-222, full length) (GST tag)

Catalog No. ABIN1046809

Product Details

Target: CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Protein Type: Recombinant

Protein Characteristics: AA 1-222, full length

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CHMP2A protein is labelled with GST tag.

Application: ELISA

Sequence: MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD

Characteristics: Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.

Purity: 90 %

Application Details

Comment:

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: 0.2-2 mg/mL

Buffer: Tris-based buffer, 50 % glycerol

Handling Advice: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week

Storage: -20 °C

Storage Comment: Store at -20 °C for extended storage, conserve at -20 °C or -80 °C

Target Details

Target: CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Alternative Name: Charged multivesicular body protein 2a protein (CHMP2A Products)

Synonyms: BC-2 Protein, BC2 Protein, CHMP2 Protein, VPS2 Protein, VPS2A Protein, 1500016L11Rik Protein, RGD1305050 Protein, bc-2 Protein, bc2 Protein, chmp2 Protein, vps2 Protein, vps2a Protein, fj10d05 Protein, wu:fi18h03 Protein, wu:fj10d05 Protein, zgc:55361 Protein, charged multivesicular body protein 2a Protein, charged multivesicular body protein 2A Protein, Charged multivesicular body protein 2a Protein, charged multivesicular body protein 2A L homeolog Protein, ATEG_06167 Protein, LOC5570080 Protein, EDI_289610 Protein, PTRG_09933 Protein, NAEGRDRAFT_39042 Protein, PITG_17335 Protein, Tsp_00033 Protein, LOC100284170 Protein, LOC100284688 Protein, chm2a Protein, chmp2a Protein, CHMP2A Protein, Chmp2a Protein, chmp2a.L Protein

Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Molecular Weight: 52.5 kD

UniProt: O43633

Pathways: SARS-CoV-2 Protein Interactome